Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent
Patent
1994-09-30
1998-10-13
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
X-ray contrast imaging agent
424 121, 424450, 424 9321, 25231501, 264 41, 436829, A61B 5055, A61K 5112, A61K 9127, B01J 1302
Patent
active
058208488
ABSTRACT:
This invention provides a composition containing a sized liposome comprising a lipid and an induce; the sized liposome has a diameter of at most about 1 micoron and the induces is present in an amount effective to induce interdigitation-fusion of the sized liposome. Also provided herein are interdigitation-fusion liposomes and gels, and methods of making the same.
REFERENCES:
patent: 3993754 (1976-11-01), Rahman et al.
patent: 4125410 (1978-11-01), Sears et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4515736 (1985-05-01), Deamer
patent: 4522803 (1985-06-01), Lenk et al.
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4560665 (1985-12-01), Nakae et al.
patent: 4588578 (1986-05-01), Fourntain
patent: 4789633 (1988-12-01), Huang et al.
patent: 4877561 (1989-10-01), Iga et al.
patent: 4921706 (1990-05-01), Roberts et al.
patent: 4944948 (1990-07-01), Uster et al.
patent: 4962022 (1990-10-01), Fleming et al.
patent: 5078986 (1992-01-01), Bosworth et al.
patent: 5312615 (1994-05-01), Schneider et al.
Ames, et al., "The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid", 1960, J. Biol. Chem., 235, 3, 769-775.
Bally, et al., "Dopamine accumulation in large unilamellar vesicles systems induced b transmembrane ion gradients", 1988, Chem. Phys., Lipids, 47, 97-107.
Boni, et al., "Aggregation and Fusion of Unilamellar Vesicles by Poly(Ethylene Glycol)", BBA 775, 1984, 409-418.
Chapman, et al., "Physical Studies of Phospholipids., X. The Effect of Sonication on Aqueous Dispersions of Egg Yolk Lecithin", BBA, 163, 255, 1968.
Chen, et al., "Micro-determination of Phosphorous", 1956, Analytical Chem., 28, 11, 1756.
Chong, P., et al. "A Differential Polarized Phase Fluorometric Study of the Effects of High Hydrostatic Pressure upon the Fluidity of Cellular Membranes", Biochemistry 1983, 22, 409-415.
Eum, et al., "Temperature-Induced Fusion of Small Unilamellar Vesicles Formed fro Saturated Long-Chain Lecithins and Diheptanolyphosphatidylcholine", Biochem., 1989, 28:8206-8213.
Lipsomes, Marc J. Ostrol, es. Marcel Dekker, Inc., New York, 1983, Chapter 1, "Liposome Preparation: Methods and Mechanisms".
Lopez-Bernstein, et al., "Liposomal Amphotericin B for the Treatment of Systemie Fungal Infections in Patients with Cancer: A Preliminary Study", 1985, J. Infect. Dis., 151, 704-710.
Mayer, etal., "Influence of Ion Gradients on the Transbilayer Distribution of Dibucaine in Large Unilamellar Vesicles:, Biochemisry, 27, 2053-2060, 1988.
Mayer et al., "Techniques for Ecapsulating Bioactive Agents into Liposomes", 1986, Chem. Phys. Lipids, 40, 333-345.
Mayer, et al. "Uptake of Adriamycin into Large Unilamellar Vesicles in Response to a pH Gradient.", BBA, 857 (1986), 123-126.
McConnell, et al., "Phospholipid vesicles fusion and drug loading: tempature, solute and cholestorol effects, and, a rapid preparation for solute-loaded vesicles", BBA, 1985, 818:13-22.
Mertens, B. "Toepassing van Hoge Isostatische Druk," VMT Voedingsmiddelentechnologie Vo 24, 24, Nov. 21, 1991, Zeist, pp. 11-14 XP 233531.
Ostro, et al., Amer. J. Hesp. Pharm., "Use of liposomes as injectable-drug delivery systems", 1989.
Perkins, et al., "The captured vol. of multimlamellar Vesicles"BBA, 1988, 943, 103-107.
Rahman, et al., "Liposomal Protection of Adriamycin-induced Cardiotoxitiy in Mice", 1980, Cancer Res., 40, 1532-1537.
Shek, et al,"Liposomes: a new generation of drug and vaccine carriers", 1986, Mod. Med. Canada, 41, 314-382.
Slater, et al., "Interdigitated Bilayer Membranes", Progress Lipid Res., 27,325-359, 1988.
Ahl Patrick L.
Boni Lawrence T.
Davis Thomas S.
Janoff Andrew S.
Minchey Sharma R.
Hartley Michael G.
Hollinden Gary E.
Rubin Kenneth B.
The Liposome Company Inc.
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