Methods of preparing bulk delivery matrices by solid-state disso

Details Methods of preparing bulk delivery matrices by solid-state disso Methods of preparing bulk delivery matrices by solid-state disso

1991-07-23

1994-07-19

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424422, 424485, A61K 914

Patent

active

053307640

ABSTRACT:
A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the solidified matrix with a second solvent that is substantially miscible with the first solvent at a temperature lower than the solidification point of the first solvent, the matrix components being substantially insoluble in the second solvent, whereby the first solvent is substantially removed resulting in a usable matrix.

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