Methods of preparing and using intravenous nutrient compositions

Details Methods of preparing and using intravenous nutrient compositions Methods of preparing and using intravenous nutrient compositions

1978-07-20

1981-08-11

Michell, Robert W.

Surgery

Truss

Perineal

128214D, 128272, 206219, A61B 1900, A61M 500, A61J 100

Patent

active

042828635

ABSTRACT:
The disclosure is of a method for preparing a stable, dry-packaged, sterile, nutrient composition which upon addition of sterile, pyrogen-free water is suitable for intravenous administration to a mammal, including a human. The method comprises providing the nutrients in a specific dry form and state of physical purity acceptable for intravenous administration, sealing the nutrients in a particular type of container adapted to receive and dispense sterile fluids and subjecting the container and its sealed contents to a sterilizing, nondestructive dose of ionizing radiation. The method results in a packaged, sterile nutrient composition which may be dissolved by the addition of sterile, pyrogen-free, water. The resulting aqueous intravenous solution may be safely administered to a mammal, including a human, in need of nutrient therapy. The packaged nutrient compositions of the invention exhibit greatly extended storage life and provide an economical method of providing intravenous solutions which are safe and efficacious for use.

REFERENCES:
patent: 3494723 (1970-02-01), Gray
patent: 3648697 (1972-03-01), Gardner
patent: 3740557 (1973-06-01), Kaushansky et al.
"Radiation Sterilization of Pharmaceuticals", Manufacturing Chemist, Powell, Nov. 1959, pp. 435-437.
"The Effect of Gamma Radiation on Some Pharmaceutical Products", JAPA, Controulis et al., Feb. 1954, pp. 65-69.
"Radiation, Foods New Keeper", Science News Letter, Tufty, 01-15-66, pp. 42-43.
"Radiation Preservation of Foods", Nature, 12-04-65, pp. 973-974.
"New Horizons in I.V. Feeding", JAMA , Feb. 8, 1971, vol. 215, No. 6, pp. 939-949.

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