Methods of preparing and purifying 9-nitro-20-camptothecin

Details Methods of preparing and purifying 9-nitro-20-camptothecin Methods of preparing and purifying 9-nitro-20-camptothecin

1997-08-05

1999-07-13

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D491147

Patent

active

059228776

ABSTRACT:
A method is disclosed for the preparation of 9-nitrocamptothecin which involves reacting 20-camptothecin with at least one inorganic nitrate salt and at least one acid effective in catalyzing the formation of a nitronium ion, where the reaction occurs at a temperature and for a time sufficient to form the 9-nitrocamptothecin. Also, methods of further purifying the 9-nitrocamptothecin by column chromatography or by reprecipatation is also disclosed.

REFERENCES:
patent: 4981968 (1991-01-01), Wall
patent: 5614628 (1997-03-01), Cabri et al.
patent: 5731316 (1998-03-01), Cao
Cotton et al. "Advanced Inorganic Chemistry" Interscience, New York, 1962 pp. 264-265.
Sawada et al. Chem. Pharm Bull. vol 39 (No. 2) pp. 3183-3188 (1991).
J.V. Crivello, "Nitrations and Oxidations with Inorganic Nitrate Salts in Trifluoroacetic Anhydride" J. Org. Chem., vol. 46, No. 15, 1981.

Affiliated with

Also associated with

Rating

Methods of preparing and purifying 9-nitro-20-camptothecin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of preparing and purifying 9-nitro-20-camptothecin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of preparing and purifying 9-nitro-20-camptothecin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2276669