Methods of prenatal screening for trisomy 21

Details Methods of prenatal screening for trisomy 21 Methods of prenatal screening for trisomy 21

2011-04-12

2011-04-12

Casler, Brian (Department: 3737)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

C382S128000

Reexamination Certificate

active

07922660

ABSTRACT:
Methods for prenatal screening for trisomy 21 employ examination of the fronto-maxillary facial (FMF) angle of a fetus. The methods may comprise obtaining a two or three dimensional image of a fetal face, measuring the FMFboneangle and/or FMFskinangle on the image, and comparing the measured FMFboneangle and/or FMFskinangle with an FMFboneangle and/or FMFskinangle characteristic of chromosomally normal fetuses. A measured FMFboneangle and/or FMFskinangle greater than the FMFboneangle and/or FMFskinangle characteristic of chromosomally normal fetuses provides an indication of an increased likelihood of the occurrence of trisomy 21 in the fetus.

REFERENCES:
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Cicero et al, “Maxillary length at 11-14 weeks of gestation in fetuses with trisomy 21,” Ultrasound Obstet. Gynecol. 2004, 24:19-22.

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