Methods of predicting therapeutic efficacy of treatment of a...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007210, C435S007900, C435S007920, C435S006120, C435S007800, C514S002600

Reexamination Certificate

active

07090982

ABSTRACT:
Methods of predicting therapeutic efficacy of treatment of a multiple sclerosis patients with peptides are provided. Multiple sclerosis patients can be screened for the presence of an human leukocyte antigen (HLA)-DR2 haplotype. The presence of the human leukocyte antigen (HLA)-DR2 haplotype in a patient is predictive of therapeutic efficacy of treatment.

REFERENCES:
patent: 6379670 (2002-04-01), Gaur et al.
patent: WO 80/02501 (1980-11-01), None
patent: WO 88/00057 (1988-01-01), None
patent: WO 95/31990 (1995-11-01), None
patent: WO 96/16085 (1996-05-01), None
patent: WO 96/28470 (1996-09-01), None
Hauser et al., 1989, Neurology, 39, pp. 275-277.
Salvetti et al., 1993, Eur. J. Immunology, 23, pp. 1232-1239.

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