Methods of obtaining compositions enriched for hematopoietic ste

Details Methods of obtaining compositions enriched for hematopoietic ste Methods of obtaining compositions enriched for hematopoietic ste

1997-02-27

1998-09-29

Schwadron, Ronald B.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

435343, 4353431, 4353432, 435372, 436518, 436536, 5303887, 53038873, 53038875, 5303896, 5303911, 530412, 530809, 935108, 424 9371, A01N 102, C12N 508, C07K 1628, C07K 1644

Patent

active

058144404

ABSTRACT:
This invention provides a novel antibody, designated .alpha.EM10, and a hybridoma cell line that produces the .alpha.EM10 antibody. Also provided are methods to obtain compositions enriched for hematopoietic stem cells. The methods employ a separation technique utilizing antibodies (.alpha.EM10) specific for a unique cell marker (EM10) that is expressed on stem and progenitor cells, while being less accessible or absent on more mature cells. Further provided are cell compositions enriched for EM10+ cells.

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