Methods of modulating β cell function

Details Methods of modulating β cell function Methods of modulating β cell function

2006-09-05

2006-09-05

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07101845

ABSTRACT:
Methods of modulating pancreatic function by modulating MCH signaling in a β cell.

REFERENCES:
patent: 6291195 (2001-09-01), Salon et al.
patent: 6329403 (2001-12-01), Odaka et al.
Bednarek et al., “Synthesis and Biological Evaluation in Vitro of Selective . . . ”, 2002, Biochem., vol. 41;6383-6390.
Boutin et al., “Melanin-concentrating hormone and it's receptors: state of the art”, 2002, Can. J. Physiol. Pharmocol., vol. 80;388-395.
Ludwig et al., Melanin-concentrating hormone overexpression in transgenic . . . , 2001, J. Clinical Investigation, vol. 107(3);379-386.
MacDonald et al., “Molecular Characterization of the Melanin-Concentrating Hormone . . . ”, 2000, Molecular Pharmacology, vol. 58;217-225.
Ozcan et al., “Melanocyte-concentrating hormone stimulates insulin release via MCH receptors expressed in islets”, Jun. 14-18, 2002, abstract presented at American Diabetes Association 62nd Annual Meeting and Scientific Sessions, San Francisco.
Vitale et al., “Conformational Features of Human Melanin-Concentrating . . . ”, 2003, ChemBioChem, vol. 4;73-81.
International Search Report for PCT/US03/02962; mailed Jun. 20, 2003.
Audinot et al., “[125I]-S30657: a new and highly potent radioligand for the melanin-concentrating hormone receptor.” Br. J. Pharmacol. 133(3):371-378 (2001).
Ludwig et al., “Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance.” J. Clin. Invest. 107 (3):379-386 (2001).
Ludwig et al., “Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus.” Am. J. Physiol. 274 (Endocrinol. Metab. 37):E627-E633 (1998).
Maulon-Ferailee et al., “Appetite-boosting property of pro-melanin-concentrating hormone(131-165) (neuropeptide-glutamic acid-isoleucine) is associated with proteolytic resistance.” J. Pharmacol. Exp. Ther. 302(2):766-773 (2002).
Rossi et al., “Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight.” Endocrinology. 138(1):351-355 (1997).
Tritos et al., “Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice.” Endocrinology. 139(11):4634-4641 (1998).

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