Methods of modulating tumor necrosis factor .alpha.-induced expr

Details Methods of modulating tumor necrosis factor .alpha.-induced expr Methods of modulating tumor necrosis factor .alpha.-induced expr

1998-12-10

2000-09-05

Elliott, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 243, 435 6, 435 911, 435 9131, 435375, 514 44, C07H 2104, C07H 2102, C12Q 168, C12N 1585, A61K 4800

Patent

active

061145173

ABSTRACT:
Methods are provided for inhibiting the expression of cell adhesion molecules using inhibitors of signaling molecules involved in human TNF-.alpha. signaling. These inhibitors include monoclonal antibodies, peptide fragments, small molecule inhibitors, and, preferably, antisense oligonucleotides. Methods for treatment of diseases, particularly inflammatory and immune diseases, associated with overexpression of cell adhesion molecules are provided.

REFERENCES:
patent: 5514778 (1996-05-01), Bennett et al.
patent: 5563255 (1996-10-01), Monia et al.
patent: 5576208 (1996-11-01), Monia et al.
patent: 5582986 (1996-12-01), Monia et al.
patent: 5591623 (1997-01-01), Bennett et al.
patent: 5656212 (1997-08-01), Monia et al.
patent: 5877309 (1999-03-01), McKay et al.
Crooke, S., Basic Principles of Antisense Therapeutics, Springer-Verlag Berlin Heidelberg New York, Jul. 1998.
Gura T., Antisense Has Growing Pains, Science, vol. 270, pp. 575-577, Oct. 1995.
Crooke, S. et al., Antisense '97: A roundtable on the state of the industry, Nature Biotechnology, vol. 15, p.522, Jun. 1997.
Branch, A., A good antisense molecule is hard to find, TIBS vol. 23, pp. 47-49, Feb. 1998.
Minden et al., Regulation and function of the JNk subgroup of MAP kinases, Biochimica et Biophysica Acta 1333 (1997), pp. F85-F104.
Min et al. TNF initiates E-selectin transcription . . . , vol. 159, 7, Journal of Immunology, pp. 3508-3518, 1997.
Bost, et al., "The JUN Kinase/Stress-activated Protein Kinase Pathway Is Required for Epidermal Growth Factor Stimulation of Growth of Human A549 Lung Carcinoma Cells", 1997; J. Biol. Chem., 272; 33422-33429.

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