Methods of modulating tubulin deacetylase activity

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S004000, C435S019000, C435S183000, C424S001110, C424S009200, C536S023200

Reexamination Certificate

active

07351542

ABSTRACT:
The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubulin deacetylase activity in a cell. The invention further provides methods of modulating cellular proliferation by modulating the activity of tubulin deacetylase.

REFERENCES:
patent: WO 89/06132 (1989-07-01), None
patent: WO 03/004621 (2003-01-01), None
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North, Brian J. et al. “The human Sir2 ortholog, SIRT2, is an NAD+− dependent tubulin deacetylase.” Molecular Cell, vol. 11, No. 2, Feb. 1, 2003, pp. 437-444.
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