Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-08-05
1999-05-11
Lee, Howard C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 21, 530810, 530813, 530817, A61K31/715;31/735
Patent
active
059027991
ABSTRACT:
Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.
REFERENCES:
patent: 2923704 (1960-05-01), Berger et al.
patent: 3420788 (1969-01-01), Solms
patent: 4020160 (1977-04-01), Bernstein et al.
patent: 4066829 (1978-01-01), Nair et al.
patent: 4247535 (1981-01-01), Lewis et al.
patent: 4258180 (1981-03-01), Lewis et al.
patent: 4383992 (1983-05-01), Lipari
patent: 4582900 (1986-04-01), Brandt et al.
patent: 4596795 (1986-06-01), Pitha
patent: 4727064 (1988-02-01), Pitha
patent: 4764604 (1988-08-01), Muller
patent: 4774329 (1988-09-01), Friedman
patent: 4834985 (1989-05-01), Elger et al.
patent: 4840941 (1989-06-01), Ueno et al.
patent: 4869904 (1989-09-01), Uekama et al.
patent: 4877774 (1989-10-01), Pitha et al.
patent: 4877778 (1989-10-01), Carpenter et al.
patent: 4902788 (1990-02-01), Zemel et al.
patent: 4912093 (1990-03-01), Michaeli
patent: 4929577 (1990-05-01), Cornell
patent: 4929602 (1990-05-01), Harker et al.
patent: 5019562 (1991-05-01), Folkman et al.
patent: 5075432 (1991-12-01), Vanzo
patent: 5100878 (1992-03-01), Geber
patent: 5135919 (1992-08-01), Folkman et al.
patent: 5164379 (1992-11-01), Koslo et al.
patent: 5183809 (1993-02-01), Weisz et al.
patent: 5248675 (1993-09-01), Kurita et al.
patent: 5637575 (1997-06-01), Herrmann et al.
patent: 5658894 (1997-08-01), Weisz
Skubitz et al. Cell. Mol. Biol., vol. 38(6): 543-560, 1992.
Teicher et al. Cancer Chemotherapy and Pharmacology, vol. 38(2): 169-177, 1996.
Chemical Abstracts, 1975, 83:79544a.
Folkman et al., 1977, Science, 235:442-447.
Chemical Abstracts, 1982, 96:218351u.
Chemical Abstracts,, 1975, 83:79544a.
Leveen et al., 1982, Investigative Radiology, 17:470-475.
Uekama et al., 1982, International Journal of Pharmaceutics, 10: 1-15.
Croft et al., 1983 Tetrahedron, 39:1717-1474.
Fenyvesi et al., 1984, Chem. Pharm. Bull., 32(2): 665-669.
Crum, "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment," 1985, Science, 230:1490-1493.
Komiyama et al., 1986, Polymer Journal, 18(4):375-377.
Pitha et al., 1986, Journal of Pharmaceutical Sciences,: 75(2):165-167.
Nakashima et al., 1987, Antimicrobial Agents and Chemotherapy, 1524-1528.
Lobb, "Clinical Applications of Heparin-Binding Growth Factors", 1988, European Journal of Clinical Investigation, 18:321-328.
Pow et al., "Low Molecular Weight Heparin Reduces Restenosis After Experimental Angioplasty," 1989, Circulation, 88(4), Supp. II.
Yamamoto et al., 1989, International Journal of Pharmaceutics, 49:163-171.
Antoniades et al., "Injury Induces In Vivo Expression of Platelet-Derived Growth Factor (PDGF) and PDGF Receptor mRNAs in Skin Epithelial Cells and PDGF mRNA in Connective Tissue Fibroblasts" 1991, Proc. Natl. Acad. Sci. USA, 88:565-569.
Herrmann, Abstracts of Papers, National Meeting of the American Heart Association, Anaheim, CA, Nov. 11-14, 1991.
Pierce et al., 1991, J. Cell Biochem., 45:319-326.
Barnathan Elliot
Herrmann Howard C.
Weisz Paul B.
Lee Howard C.
The Trustees of the University of Pennsylvania
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