Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-12-05
2006-12-05
Paras, Jr., Peter (Department: 1632)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210
Reexamination Certificate
active
07144706
ABSTRACT:
The present invention relates, generally, to inositol 1,4,5-triphosphate receptors (IP3R), and, in particular, to methods of modulating the activity of 220 kDa ankyrin-B in cellular localization and physiological function of IP3R. The invention further relates to methods of identifying compounds suitable for use in such methods and to compounds so identified.
REFERENCES:
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Mohler et al, “Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death”, Nature 421:634-639 (2003).
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Bennett Vann
Gramolini Anthony O.
Mohler Peter J.
Duke University
Montanari David A.
Nixon & Vanderhye PC
Paras, Jr. Peter
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