Methods of modulating cold sensory perception via a cold-...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007210, C435S029000, C435S069100, C435S252300, C435S325000, C435S471000

Reexamination Certificate

active

07838253

ABSTRACT:
The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.

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Clapham, David E. et al.; “The TRP ION Channel Family”; 2001,Nature Reviews, vol. 2, pp. 387-395.
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