Methods of modulating cell migration using galectin-3

Details Methods of modulating cell migration using galectin-3 Methods of modulating cell migration using galectin-3

2007-03-06

2007-03-06

Landsman, Robert S. (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S143100

Reexamination Certificate

active

09805449

ABSTRACT:
The present invention relates to methods of modulating cell migration, particularly, monocyte, neutrophil or macrophage migration, using galectin-3, galectin-3 binding polypeptide, or galectin-3 receptor binding polypeptide. Specifically provided are methods for increasing cell migration to sites of inflammation, infection or a tumor. Also provided are methods for identifying agents that modulate galectin-3 mediated migration, compositions containing galectin-3 or a functional subsequence thereof, and microfabricated devices that deliver galectin-3 or functional galectin-3 subsequences.

REFERENCES:
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Nangia-Makker et al.; Galectin-3 Induces Endothelial Cell Morphogenesis and Angiogenesis; American Journal of Pathology, vol. 156, No. 3; Mar. 2000; pp; 899-909.
Yang et al.; Expression of galectin-3 modulates T-cell growth and apoptosis, Proc. Natl. Acad. Sci. USA, vol 93; Jun. 1996; pp. 6737-6742.
Frigeri et al.; εBP, a β-Gelactoside-Binding Animal Lectin, Recognizes IgE Receptor (FcεRI) and Activates Mast Cells; Biochemistry, vol. 32; No. 30: 1993;pp. 7644-7649.

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