Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
2000-02-04
2000-11-07
Yucel, Remy
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 4, 435 6, 435455, 536231, 530300, 530350, C12Q 168, C12N 1511, C07H 2104, C07K 500, C07K 1400
Patent
active
061435228
ABSTRACT:
The invention provides novel methods for modulating apoptosis in eukaryotic cells using peptides and proteins derived from p33.sup.ING1 or oligonucleotides derived from the ING1 gene. The invention also provides method of determining the apoptotic characteristic of a eukaryotic cell.
REFERENCES:
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5589466 (1996-12-01), Felgner et al.
Aharon, T. et al., "Selective Destabilization of Short-Lived mRNAs with the Granulocyte-Macrophage Colony-Stimulating Factor AU-Rich 3' Noncoding Region is Mediated by a Cotranslational Mechanism", Mol. Cell. Biol. 13:1971-1980 (1993).
Anderson, W. French, "Human gene therapy", Science 256:808-813 (May 1992).
Atadja, P. et al., "Increased activity of p53 in senescing fibroblasts" Proc. Nat'l. Acad. Sci. USA 92: 8348-8352 (1995).
Bond, et al., "Escape from senescence in human diploid fibroblasts induced directly by mutant p53" Oncogene 9:1885-1889 (1994).
Culver et al., "In Vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors", Science 256:1550-1552 (Jun. 1992).
Defeo-Jones, D., "Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product", Nature 352:251-254 (1991).
Demetrick, D.J., "Fluorescence in situ hybridization and human cell cycle genes" In the Cell Cycle--Materials and Methods M. Pagano (ed.) Springer Verlag Press, 29-45 (1995).
El-Deiry, W.S. et al., "WAF1, a Potential Mediator of p53 Tumor Suppression", Cell 75:817-825 (1993).
Galli & Fratelli, "Activation of apoptosis by serum deprivation in a teratocarcinoma cell line: inhibition by L-acetycarnitine", Exp. Cell Res. 204:54-60 (1993).
Garkavtsev et al. (1996), "Suppression of the novel growth inhibitor p33.sup.ING 1 promotes neoplastic transformation", Nature Genetics, 14(4):415-420.
Garkavtsev et al. "The candidate tumor suppressor p33.sup.ING1 cooperates with the p53 in cell growth control", Nature 391:295-298 (1998).
Gossen and Bujard, "Tight control of gene expression in mammalian cells by tetracycline-responsive promoters", Proc. of Natl Acad. Sci. 89(12):5547-5551 (1992).
Graessmann and Graessmann, "Microinjection of tissue culture cells", Methods in Enzymology 101:482-492 (1983).
Guan, K. et al., "Growth suppression by p18, a p16.sup.INK4/MTS1 and p14.sup.INK4B/MTS2 -related CDK6 inhibitor, correlates with wild-type pRb function", Genes & Dev. 8:2939-2952 (1994).
Gudkov, A.V. et al., "Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA", Proc. Natl. Acad. Sc. USA 90:3231-3235 (1993).
Gudkov, A. et al., "Cloning mammalian genes by expression selection of genetic suppressor elements: Associate of kinesin with drug resistance and cell immortalization" Proc. Nat'l Acad. Sci. USA 91:3744-3798 (1994).
Harper, J.W. et al., "The p21 Cdk-Interacting Protein Cip1 is a Potent Inhibitor of G1 Cyclin-Dependent Kinases", Cell 75:805-816 (1993).
Helbing, et al., "A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis" Cancer Research 53:1255-1258 (1997).
Hillier et al., Database CST on MPSRcrhAccession No. T60958.
Hillier et al., (Feb. 1995), "Database EMBL Entry HS12525", WashU-EST Project .
Hunter, T. et al., "Cyclins and Cancer II: Cyclin D and CDK Inhibitors Come of Age", Cell 79:573-582 (1994).
Kamb, A. et al., "A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types", Science 264:436-440 (1994).
Kaneko, et al., "Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression" Cancer Research 55:5283-5287 (1995).
Lee and Bernstein, "Apoptosis, cancer and the p53 tumor suppressor gene" Cancer Met Rev. 14:149-161 (1995).
Levine, A.J., "The Tumor Suppressor Genes", Annu. Rev. Biochem. 62:623-651 (1993).
Levine (1997), "p53, the Cellular Gatekeeper for Growth and Division", Cell 88:323-331.
Lisitsyn, N. et al., "Cloning the Differences Between Two Complex Genomes", Science 259:946-951 (1993).
Maestro et al., "Chromosome 13q deletion mapping in head and neck squamous cell carcinomas: identification of two distinct regions of preferential loss" Cancer Research 56:1146-1150 (1996).
Meikrantz and Schlegel, "Apoptosis and the cell cycle" J. Cell Biochem 58:160-174 (1995).
Miller, A.D. et al., "Improved Retroviral Vectors for Gene Transfer and Expression", Biotechniques 7:980-986 (1989).
Miller, Dusty A., "Human gene therapy comes of age" Nature 357:455-460 (Jun. 1992).
Mitelman et al., "Report of the committee on chromosome changes in neoplasia" Cytogenet Cell Genet 55:358-386 (1990).
Motomura et al., "Loss of alleles at loci on chromosome 13 in human primary gastric cancers" Genomics 2, 180-184 (1988).
Nobori, T. et al., "Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers", Nature 368:753-756 (1994).
Pear, W.S. et al., "Production of high titer helper-free retroviruses by transient transfection" Proc. Natl. Acad. Sci. 90:8392-8396 (1993).
Riabowol, K. et al., "The cdc2 Kinase Is a Nuclear Protein That Is Essential for Mitosis in Mammalian Cells", Cell 57:393-401 (1989).
Schneider E.L and Fowlkes, B.J., "Measurement of a DNA content and cell volume in senescent human fibroblasts utilizing flow miltiparameter single cell analysis" Exp. Cell. Res. 98:298-302 (1976).
Serrano, M. et al., "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4", Nature 366:704-707 (1993).
Smith et al., "Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures", Nature 337:181-184 (1989).
Straus, D. et al., "Genomic subtraction for cloning DNA corresponding to deletion mutations", Proc. Natl. Acad. Sc. USA 87:1889-1893 (1990).
Thompson, M.E. et al., "Decreased expression of BRCA-1 accelerates growth and is often present during sporadic breast cancer progression" Nature Genetics 9:444-450 (1995).
Tsai, L.H. et al., "The cdk2 kinase is required for the G1- to -S transition in mammalian cells" Oncogene 8:1593-1602 (1993).
Weinberg, Robert A. (1991), "Tumor Suppressor Genes", Science, 254:1138-1146.
Wong, H. et al., "Monitoring mRNA expression by polymerase chain reaction: the "primer-dropping" method" Anal. Biochem. 223:251-258 (1994).
Xlong et al., (1993) "p21 is a Universal Inhibitor of Cyclin Kinases", Nature 366:701-704.
Yang, Y. et al., "An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer" Proc. Nat'l. Acad. Sci. USA 90: 4061-4605 (1993).
Yaswen, P. et al., "Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells", Proc. Natl. Acad. Sc. USA 87:7360-7364 (1990).
Garkavtsev Igor
Helbing Caren C.
Johnston Randall N.
Riabowol Karl
McGarry Sean
University Technologies International Inc.
Yucel Remy
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