Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2009-02-19
2010-10-26
Carlson, Karen Cochrane (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S069100, C530S350000, C424S682000
Reexamination Certificate
active
07820397
ABSTRACT:
Methods are provided for identifying agents that modulate intracellular calcium. Also provided are methods of modulating calcium within cells and methods of identifying proteins involved in modulating intracellular calcium.
REFERENCES:
patent: 4716150 (1987-12-01), Van Eldik et al.
patent: 6171864 (2001-01-01), Coughlan et al.
patent: 2002/0034728 (2002-03-01), Normant et al.
patent: WO-99-32619 (1999-07-01), None
patent: WO-02-30976 (2002-04-01), None
Arnaudeau et al., “Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria.” J. Biol. Chem. 29:277(48):46696-46705 (2002).
Cahill, J., “Protein and antibody arrays and their medical applications,” Immunol. Meth. 250:81-91 (2001).
Chan et al., “Structural characteristics that govern binding to, and modulation through, the cardiac ryanodine receptor nucleotide binding site,” Mol. Pharmacol. 63(1):174-182 (2003).
Churchill and Louis, “Imaging of intracellular calcium stores in single permeabilized lens cells,” Am. J. Physiol. 276(2 Pt 1):C426-434 (1999).
Clemens et al., “Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways,” PNAS USA 97:6499-6503 (2000).
Correa et al., “Structural determinants of adenophostin A activity at inositol trisphosphate receptors,” Mol. Pharmacol. 59(5):1206-1215 (2001).
Eroshkin et al., “Algorithm and computer program Pro—Anal for analysis of relationship between structure and activity in a family of proteins or peptides,” Comput. Appl. Biosci. 9:491-497 (1993).
Fanger et al., “Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels,” J. Cell Biol. 131:655-657 (1995).
Feske et al., “Gene regulation mediated by calcium signals in T lymphocytes,” Nature Immunol. 2:316-324 (2001).
Hanes and Pluckthun, “In vitro selection and evoluation of functional proteins by using ribosome display,” PNAS USA 13:4937-4942 (1997).
Karvonen et al., “Psoriasis and altered calcium metabolism: downregulated capacitative calcium influx and defective calcium-mediated cell signaling in cultured psoriatic keratinocytes,” J. Invest. Dermatol. 114:693-700 (2000).
Koi et al., “Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11,” Science 260:361-364 (1993).
LeDeist et al., “A primary T-cell immunodeficiency associated with defective transmembrane calcium influx,” Blood 85:1053-1062 (1995).
Martin et al., “Relation between phosphatidylserine exposure and store-operated Ca2+ entry in stimulated cells,” Biochem. Biophys. Res. Commun. 279:639-645 (2000).
Martinez et al., “Significance of capacitative Ca entry in the regulation of phosphatidylserine expression at the surface of stimulated cells,” Biochem. 38:10092-10098 (1999).
Michalak et al., “Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulum,” Cell Calcium 32:269-278 (2002).
Minta et al., “Fluorescent indicators for cytosolic calcium based on Rhodaminc and Fluorescein chromphores,” J. Biol. Chem. 264(14):8171-8178 (1989).
Ng and Henikoff, “Predicting deleterious amino acid substitutions,” Genome Res. 11(5):863-874 (2001).
Oritani and Kincade, “Identification of stromal cell products that interact with pre-B cells,” J. Cell Biol. 134:771-782 (1996).
Partiseti et al., “The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency,” J. Biol. Chem. 269:32327-32335 (1994).
Petersen et al., “The role of endplasmic reticulum calcium pumps during cytosolic calcium spiking in pancreatic acinar cells,” J. Biol. Chem. 268(30):22262-22264 (1993).
Rodi et al., “One from column A and two from column B: the benefits of phage display in molecular-recognition studies,” Curr. Opin. Chem. Biol. 6:92-96 (2002).
Rubinson et al., “A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference,” Nature Genet. 33:401-406(2003) and Corrigendum, vol. 39(6):803 (2007).
Suzuki et al., “Design and synthesis of calcium and magnesium ionophores based on double-armed diazacrown ether compounds and their application to an ion-sensing component for an ion-selective electrode,” Anal. Chem. 67:324-334 (1995).
Tiscornia et al., “A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA,” PNAS 100:1844-1848 (2003).
Welch, “Quantitative relationships between ryanoids, receptor affinity, and channel conductance,” Frontiers in Bioscience 7:1727-1742 (2002).
Wikipedia entry for HEK cells, http://en.wikipedia.org/wiki/Hek293#Origins—of—HEK—Cells.
Williams et al., “Identification and characterization of the STIM (stromal inreraction molecule) gene family: coding for a novel class of transmembrane proteins,” Biochem. J. 357:673-685 (2001).
Williams et al., “Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation,” Biochim. Biophys. Acta 1596:131-137 (2002).
Xu et al., “Specific structural requirements for the inhibitory effect of Thapsigargin on the Ca2+ATPase SERCA,” J. Biol. Chem. 279(17):17973-17979 (2004).
SIFT Algorithm, http://blocks.fhcrc.org/sift/SIFT.html, printed on Jul. 24, 2008.
Digregorio Paul J.
Ohlsen Kari Lynn
Roos Jack
Stauderman Kenneth A.
Velicelebi Gonul
Calcimedica, Inc.
Carlson Karen Cochrane
Kosson Rosanne
Wilson Sonsini Goodrich & Rosati
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