Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1996-06-04
1999-11-23
Caputa, Anthony C.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
436503, 435 72, 435 721, G01N 33566
Patent
active
059899204
ABSTRACT:
This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has the structure: ##STR1## In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.
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Branchek Theresa
Gerald Christophe P. G.
Walker Mary W.
Weinshank Richard L.
Caputa Anthony C.
Gucker Stephen
Synaptic Pharmaceutical Corporation
White John P.
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