Methods of modifying carbohydrate moieties

Details Methods of modifying carbohydrate moieties Methods of modifying carbohydrate moieties

1994-12-30

1998-11-10

Rollins, John W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 72, 435 85, 435 97, 435 99, 435 691, 435171, 435 681, C12P 2100, C12P 1918, C12P 102

Patent

active

058342516

ABSTRACT:
The invention is directed to methods of converting high mannose type glycosylation patterns to hybrid or complex type glycosylation patterns.

REFERENCES:
patent: 4770994 (1988-09-01), Rittenhouse
patent: 5180674 (1993-01-01), Roth
patent: 5272066 (1993-12-01), Bergh et al.
patent: 5324663 (1994-06-01), Lowe
Burke, J. et al., "The Transmembrane and Flanking Sequences of .beta.1,2-N-Acetylglucosaminytransferase I Specify medial-Golgi Localization," J. Biol. Chem. 267(34):24433-24440 (1992).
Carrez, D. et al., "Heterologous gene expression by filamentous fungi: secretion of human interleukin-6 by Aspergillus nidulans, " Gene 94:147-154 (1990).
Chiba, Y. et al., "The Carbohydrate Moiety of the Acid Carboxypeptidase from Aspergillus saitoi, " Curr. Microbial. 27:281-288 (1993).
Contreras R. et al., "Efficient Kex2-like Processing of a Glucoamyase-Interleukin-6 Fusion Protein by Aspergillus nidulans and Secretion of Mature Interleukin-6," Bio/Technology 9:378-381 (1991).
Dwek, R.A. et al., "Analysis of Glycoprotein-Associated Oligosaccharides," Annu. Rev. Biochem. 62:65-100 (1993).
Harkki, A. et al., "A Novel Fungal Expression System: Secretion of Active Calf Chymosin from the Filamentous Fungus Trichoderma reesei," Bio/Technology 7:596-601 (1989).
Keskar, S.S. et al., "Production and Properties of .alpha.-Mannosidase from Aspergillus sp.," Biotech. Lett. 15(7):685-690 (1993).
Kukuruzinska, M.A. et al., "Protein Glycosylation in Yeast," Ann. Rev. Biochem. 56:915-944 (1987).
Nevalainen, H., "Genetic Improvement of Enzyme Production in Industrially Important Fungal Strains," Presented at the Univ. of Helsinki on Nov. 29, 1985.
Salovuori, I. et al., "Low Molecular Weight High-Mannose Type Glycans in a Secreted Protein of the Filamentous Fungus Trichoderma reesei," Bio/Technology 5:152-156 (1987).
Schachter, Hl., "The `yellow brick road` to branched complex N-glycans," Glycobiology 1(5):453-461 (1991).
Shoemaker, S. et al., "Characterization and Properties of Cellulases Purified From Trichoderma reesei Strain L27," Bio/Technology 1:687-690 (1983).
Stanley, P., "Chinese Hamster Ovary Cell Mutants with Multiple Glycosylation Defects for Production of Glycoproteins with Minimal Carbohydrate Heterogeneity," Molec. Cell. Biol. 9(2):377-383 (1989).
Stanley, P., "Glycosylation engineering ," Glycobiology 2(2):99-107 (1992).
Uusitalo, J.M. et al., "Enzyme production by recombinant Trichoderma reesei strains," J. Biotech. 17:35-50 (1991).
van den Hondel, C. et al., "Heterologous Gene Expression in Filamentous Fungi," in: More Gene Manipulations in Fungi, Bennett et al., eds., pp. 396-428 (1991).
Van Brunt, J., "Fungi: The Perfect Hosts?" Bio/Technology 4:1057-1059 and 1060-1062 (1986).
Varki, A., "Biological roles of oligosaccharides: all of the theories are correct," Glycobiology 3(2):97-130 (1993).
Toone et al, Tetrahedron 45(17): 5365-5422 (1989).

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