Methods of manufacturing crystalline forms of rapamycin analogs

Details Methods of manufacturing crystalline forms of rapamycin analogs Methods of manufacturing crystalline forms of rapamycin analogs

2007-07-23

2010-10-26

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07820812

ABSTRACT:
A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.

REFERENCES:
patent: 6015815 (2000-01-01), Mollison
patent: 2003/0129215 (2003-07-01), Mollison et al.
patent: 2008/0085880 (2008-04-01), Viswanath et al.
patent: WO 99/15530 (1999-04-01), None
patent: 2006/023627 (2006-03-01), None
patent: 2006/060616 (2006-06-01), None
patent: WO 2008/014222 (2008-01-01), None
Wagner et al, “Rapamycin Analogs With Reduced Systemic Exposure” Bioorganic & Medicinal Chemistry Letters 2005.
Pagano, Thomas G. “Spectral Assignments and Reference Data”, Magnetic Resonance in Chemistry, Dec. 13, 2004.
European Search Reprot for 07799771.6, mailed Sep. 23, 2009, 7 pgs.

Affiliated with

Also associated with

Rating

Methods of manufacturing crystalline forms of rapamycin analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of manufacturing crystalline forms of rapamycin analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of manufacturing crystalline forms of rapamycin analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4187935