Methods of manufacturing crystalline forms of rapamycin analogs

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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Reexamination Certificate

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07820812

ABSTRACT:
A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.

REFERENCES:
patent: 6015815 (2000-01-01), Mollison
patent: 2003/0129215 (2003-07-01), Mollison et al.
patent: 2008/0085880 (2008-04-01), Viswanath et al.
patent: WO 99/15530 (1999-04-01), None
patent: 2006/023627 (2006-03-01), None
patent: 2006/060616 (2006-06-01), None
patent: WO 2008/014222 (2008-01-01), None
Wagner et al, “Rapamycin Analogs With Reduced Systemic Exposure” Bioorganic & Medicinal Chemistry Letters 2005.
Pagano, Thomas G. “Spectral Assignments and Reference Data”, Magnetic Resonance in Chemistry, Dec. 13, 2004.
European Search Reprot for 07799771.6, mailed Sep. 23, 2009, 7 pgs.

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