Methods of manufacturing betulinic acid

Details Methods of manufacturing betulinic acid Methods of manufacturing betulinic acid

1997-03-27

1998-09-08

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552502, A61K 3156

Patent

active

058045759

ABSTRACT:
Improved methods of manufacturing betulinic acid from betulin are disclosed. The methods provide the .beta.-isomer of betulinic acid in high purity and high yield.

REFERENCES:
von L. Ruzicka et al., Helv. Chim. Acta., 21, 1706-1717 (1938).
Robertson et al., J. Chem. Soc., 1267-1273 (1939).
Aplin et al., J. Chem. Soc., 3269-3273 (1963).
Pakrashi et al., Phytochemistry, 7, 461-466 (1968).
Krajniak et al., Aust. J. Chem., 22, 1331-1332 (1969).
Plattner et al., J. Am. Chem. Soc., 94:24, 8613-8615 (1972).
Greene et al., Protective Groups in Organic Synthesis, John Wiley and Sons, Inc., NY, NY (1991).
Fujioka et al., Journal of Natural Products, 57, No. 2, 243-247 (1994).
Pisha et al., Nature Medicine, 1, No. 10, 1046-1051 (1995).

Affiliated with

Also associated with

Rating

Methods of manufacturing betulinic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of manufacturing betulinic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of manufacturing betulinic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1282322