Methods of making ureas and guanidines including, terazosin, pra

Details Methods of making ureas and guanidines including, terazosin, pra Methods of making ureas and guanidines including, terazosin, pra

1997-09-29

2000-06-27

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

540575, 544284, 544367, 544374, 544377, 544379, 544388, 544390, 558385, 558386, 558413, 558417, C07C27570, C07D40704, C07D24104

Patent

active

060808608

ABSTRACT:
Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.

REFERENCES:
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Synthetic Communications, vol. 18, No. 5, May 1988, U.S. pp. 525-530, A.V.N. Reddy, et al.: An Efficient Synthesis of 3,4-dihydro-4-imino-2(1H)-quinazolines'.
Houben-Weyl: `Methoden der Organischen Chemie`, Band E4, 1983, pp. 352-364, published by Georg Thieme Verlag, Stuttgart, DE.
Houben-Weyl: 'Methoden der Organischen Chemie', Band E4, 1983, pp. 608-619, published by Georg Thieme Velag, Stuttgart, DE.
Althius, T.H. and Hess, H.J., "Synthesis and Identification of the Major Metabolites of Prazosin Formed in Dog and Rat", Journal of Medicinal Chemistry vol. 20 p. 146 (1977).
Reiter, J. and Pongo, L, "On Triazoles. V[1,2],Synthesis of 1-and 2-R.sup.1 -3-R.sup.2,R.sup.3 -Amino-5-amino-1,2,4-triazoles", Journal of Heterocyclic Chemistry vol. 23, p. 401 (1986).
Curd, F.H.S., Landquist, J.K. and Rose, F.L., "Synthetic Animalarials, Part XXXII. 2-p-Chloroanilino-4-.beta.-di-ethylaminoethylaminoquinazolines containing Various Substituents in the Quinazoline Nucleus", Journal of the Chemical Society, p. 1759 (1948).

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