Methods of making ureas and guanidines, including terazosin, pra

Details Methods of making ureas and guanidines, including terazosin, pra Methods of making ureas and guanidines, including terazosin, pra

1995-05-30

1997-11-11

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544291, C07D40302, C07D40306

Patent

active

056866127

ABSTRACT:
Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.

REFERENCES:
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patent: 3949089 (1976-04-01), Maxwell
patent: 4026894 (1977-05-01), Winn et al.
patent: 4138561 (1979-02-01), Crenshaw et al.
patent: 4251532 (1981-02-01), Roteman
Synthetic Communications, vol. 18, No. 5, May 1988, U.S. pp. 525-530, A.V.N. Reddy, et al.: "An Efficient Synthesis of 3,4-dihydro-4-imino-2(1H)-quinazolines".
Houben-Weyl: `Methoden der Organischen Chemie`, Band E4, 1983, pp. 352-364, published by George Thieme Verlag, Stuttgart, DE.
Houben-Weyl: `Methoden der Organischen Chemie`, Band E4, 1983, pp. 608-619, published by Georg Thieme Verlag, Stuttgart, DE.
Pruszynski, Canadian Journal of Chemistry, 65, 626-9(1987).

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