Methods of making ureas and guanidines, including, terazosin, pr

Details Methods of making ureas and guanidines, including, terazosin, pr Methods of making ureas and guanidines, including, terazosin, pr

1995-05-30

1997-10-07

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544284, 544285, 544286, 544287, 544288, 544289, 544290, 544291, 544292, 544293, 514259, 514260, C07D40300, C07D40302

Patent

active

056750064

ABSTRACT:
Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.

REFERENCES:
patent: 3511836 (1970-05-01), Maxwell et al.
patent: 3949089 (1976-04-01), Pfizer
patent: 4026894 (1977-05-01), Winn et al.
patent: 4138561 (1979-02-01), Crenshaw et al.
patent: 4251532 (1981-02-01), Roteman
Synthetic Communications, vol. 18, No. 5, May 1988, U.S. pp. 525-530, A.V.N. Reddy, et al.: "An Efficient Synthesis of 3,4-dihydro-4-imino-2(1H)-quinazolines'".
Houben-Weyl: `Methoden der Organischen Chemie`, Band E4, 1983, pp. 352-364, published by Georg Thieme Verlag, Stuttgart, DE.
Houben-Weyl: `Methoden der Organischen Chemie`, Band E4, 1983, pp. 608-619, published by Georg Thieme Verlag, Stuttgart, DE.
Althius, T.H. and Hess, H.J., "Synthesis and Identification of the Major Metabolites of Prazosin Formed in Dog and Rat", Journal of Medicinal Chemistry vol. 20, p. 146 (1977). 2-R.sup.1 -3-R.sup.2,R.sup.3 -Amino-5-amino-1,2,4-triazoles", Journal of Heterocyclic Chemistry, vol. 23, p. 401 (1986).
Curd, F.H.S., Landquist, J.K. and Rose, F.L., "Synthetic Antimalarials, Part XXXII. 2-p-Chloroanilino-4-.beta.-di-ethylaminoethylaminoquinazolines containing Various Substituents in the Quinazoline Nucleus", Journal of the Chemical Society, p. 1759 (1948).

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