Methods of making propoxphene derivatives

Details Methods of making propoxphene derivatives Methods of making propoxphene derivatives

1997-04-28

1998-10-06

Ceperley, Mary E.

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

Producing labeled antigens

435188, 436533, 436545, 436546, 436815, 436544, 530405, 530807, G01N 33532, G01N 33533, G01N 33534, G01N 33535

Patent

active

058175296

ABSTRACT:
The present invention provides hapten derivatives that are useful for the preparation of antigenic, antibody and label reagents having superior performance characteristics for use in immunoassays for the detection of d-propoxyphene and d-nor-propoxyphene. In the present invention the propoxyphene nucleus is derivatized out of the nitrogen center to form an aminoalkyl -carboxyl, -amino, -thiol or -hydroxyl haptenic derivative. The resulting hapten can then be further modified at the now functionalized position off the nitrogen for linking to an appropriate antigenic or labelling group to provide reagents for propoxyphene immunoassays having excellent sensitivity and selectivity for both d-propoxyphene and d-nor-propoxyphene.

REFERENCES:
patent: 4025501 (1977-05-01), Leute
patent: 4067774 (1978-01-01), Rubenstein et al.
patent: 5239086 (1993-08-01), Dubler et al.
patent: 5492841 (1996-02-01), Craig
Frigola et al., Farmaco Ed. Sci. 43(4) 347-362 (1988).
McMahon et al., Life Sci. 12(10) (Pt. 2) 463-73 (1973).
Derwent Abstract- AN 87-016372/03.

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