Methods of making liposomes containing hydro-monobenzoporphyrin

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Diagnostic or test agent produces in vivo fluorescence

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 96, 424 91, A61K 4900, G01N 3100, G01N 3348

Patent

active

057076081

ABSTRACT:
Liposomal compositions containing green porphyrins as photosensitizers are improved by enhancing the ratio of phospholipid to photosensitizer and by conducting the hydration an sizing of the liposomes in the composition at low temperature.

REFERENCES:
patent: 4485806 (1984-12-01), Akers
patent: 4500507 (1985-02-01), Wong
patent: 4517762 (1985-05-01), Venetz
patent: 4577636 (1986-03-01), Spears
patent: 4649151 (1987-03-01), Dougherty et al.
patent: 4753958 (1988-06-01), Weinstein et al.
patent: 4776991 (1988-10-01), Farmer et al.
patent: 4866168 (1989-09-01), Dougherty et al.
patent: 4883790 (1989-11-01), Levy et al.
patent: 4889129 (1989-12-01), Dougherty et al.
patent: 4920143 (1990-04-01), Levy et al.
patent: 4932934 (1990-06-01), Dougherty et al.
patent: 4933121 (1990-06-01), Law et al.
patent: 5010073 (1991-04-01), Kappas et al.
patent: 5053423 (1991-10-01), Liu
patent: 5214036 (1993-05-01), Allison et al.
patent: 5238940 (1993-08-01), Liu et al.
patent: 5270053 (1993-12-01), Schneider et al.
patent: 5389378 (1995-02-01), Madden
patent: 5422362 (1995-06-01), Vincent et al.
Kessel et al (Eds), "Porphyrin Photosensitization", Plenum Press (1983).
Diamond, et al., "Photodynamic Therapy of Malignant Tumours," Lancet, 2:1175-77 (1972).
Dougherty et al., "Photoradiation Therapy of Human Tumors, in The Science of Photo Medicine", 625-38 (Regan et al., eds. 1982).
Dougherty et al., "Photosensitizers," in Cancer: Principles and Practice of Oncology, 1836-44 (DeVita Jr., et al., eds. 1982).
Johnson et al., "Comparison studies of selected prophyrin photosensitizers," Proc. Photodynamic Therapy: Mechanisms II, Proc. SPIE-Int. Soc. Opt. Eng., 1203:266-80 (1990).
Jori et al., "Preferential delivery of liposome-incorporated porphyrins to neoplastic cells in tumour-bearing rats," Br. J. Cancer, 48:307-309 (1983).
Lipson et al., "The Use of a Derivative of Hematoporphyrin in Tumour Detection," J. Natl. Cancer Inst., 26:1-8 (1961).
Milanesi et al., "Photokinetic and ultrastructural studies on porphyrin photosensitization of HeLa cells," Int. J. Radiat. Biol., 55:59-69 (1989).
Ricchelli, "Liposomes as carriers of hydrophobic photosensitizers in vivo: increased selectivity of tumor targeting," New Directions in Photodynamics Therapy, 847:101-106 (1987).
Schweitzer et al., "Photodynamic therapy for treatment of AIDS-related oral Kaposi's sarcoma," Otolaryngology--Head and Neck Surgery, 102:639-49 (1990).
Spikes et al., "Photodynamic Therapy of Tumours and Other Diseases Using Porphyrins," Lasers in Medical Science, 2:3-15 (1987).
Weishaupt et al., "Identification of Singlet Oxygen as the Cytotoxic Agent in Photo-inactivation of a Murine Tumor," Cancer Research, 36:2326-29 (1976).
Zhou et al., "An Ultrastructural Comparative Evaluation of Tumors Photosensitized by Porphyrins Administered in Aqueous Solution, Bound toLiposomes or to Lipoproteins," Photochemistry and Photobiology, 48:487-92 (1988).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of making liposomes containing hydro-monobenzoporphyrin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of making liposomes containing hydro-monobenzoporphyrin , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of making liposomes containing hydro-monobenzoporphyrin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-323992

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.