Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-02-19
2000-09-12
McKane, Joseph
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D21716
Patent
active
06117999&
ABSTRACT:
HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.
REFERENCES:
patent: 5063208 (1991-11-01), Rosenberg et al.
patent: 5142056 (1992-08-01), Kempe et al.
patent: 5157041 (1992-10-01), Handa et al.
patent: 5196438 (1993-03-01), Martin et al.
patent: 5204471 (1993-04-01), Negele et al.
patent: 5235039 (1993-08-01), Health, Jr. et al.
patent: 5256783 (1993-10-01), Gokhale et al.
patent: 5434265 (1995-07-01), Fritz et al.
patent: 5463104 (1995-10-01), Vasquez et al.
patent: 5484926 (1996-01-01), Dressman et al.
patent: 5514802 (1996-05-01), Fritz et al.
patent: 5527829 (1996-06-01), Kalish
patent: 5705647 (1998-01-01), Babu et al.
Tam et al., J. Med. Chem., 35(7):1318-1320 (1992).
Huff, J. Med. Chem., 34(8):2305-2314 (1991).
Ghosh et al., J. Med. Chem., 36(2):292-294 (1993).
Ghosh et al., J. Med. Chem. 36(16):2300-2310 (1993).
Thompson et al., J. Am. Chem. Soc., 115(2):801-802 (1993).
Rich et al., J. Med. Chem., 34(3):1222-1225 (1991).
Thaisrivongs et al., J. Med. Chem., 34(8):2344-2356 (1991).
Ghosh et al., J. Med. Chem., 36(7):924-927 (1993).
Chong et al., J. Med. Chem., 36:2575-2577 (1993).
Prasad et al., Peptides, Chemistry and Biology, Proceedings of the Twelfth American Peptide Symposium, pp. 721-722 (1991).
Rich et al., Chem. Abstracts, 114(15) Abstract No. 143998g (1991).
Houpis et al., Tetrahedron Letters, 34(16):2593-2596 (1993).
Roberts, et al., Science, 248:358-361 (1990).
Gilbert et al., J. Chem. Soc. Perkin Trans., 2:475-479 (1993).
Young et al., J. Med. Chem., 35(10):1702-1709 (1992).
Lyle et al., J. Med. Chem., 34(3):1228-1230 (1991).
Peltier et al., "Contribution a l'etude du groupe carboxylique. Absorption infrarouge et ionisation," Bulletin de la Societe chimique de France, 1960, 1141-1147.
Mukharji et al., Indian J. Chem., EN, 9, 1971, 515-523, as abstracted in Database Xfire< Beilstein, 3-methoxy-2-methyl-benzoic acid ethyl ester.
Ratner et al., Complete nucleotide dequence of the AIDS virus, HTLV-III, Nature, vol. 313, Jan. 24, 1985.
Rose et al., "Regulation of Autoproteolysis of the HIV-1 and HIV-2 Proteases with Engineered Amino Acid Substitutions", Journal of Biological Chemistry, vol. 268, No. 16, pp. 11939-11945 (1993).
Menge et al., "Structure-Function Analysis of the Mammalian DNA Polymerase Active Site: role of Aspartic Acid 256, Arginine 254, and Arginine 258 in Nucleotidyl Transfer", Biochemistry 1995, 34, 19934-15942.
Celis et al., "Chain-terminating Mutants Affecting a Periplasmic Binding Protein Involved in the Active Transport of Arginine and Ornithine in Escherichia coli", Journal of Biological Chemistry, vol. 256, No. 2, pp. 773-779, 1981.
Morrison, Lometocs pf tje reversob;e Omjobotopm pf Emzu,e-Catalysed Reactions by Tight-Binding Inhibitors, Biochim. Biophys. Acta, 185 (1969) 269-286.
Alley, et al., "Feasibility of Drug Screening with Panels of Human Tumor Cell Lines Using a Microculture Tetrazolium Assay", Cancer Research, 48, 589-601, Feb. 1, 1988.
J. Townsend, et al., "Novel Copper Complexes of Chiral Diphosphines: Preparation, Structure, and Use to Form Rhodium Complex Catalysts for Chiral Hydrogenations", J. Org. Chem., 1980; 45, pp. 2995-2999.
S. Takano, et al., "Selective Manipulation of Hydroxy Groups in (2S,3S)-Threitol", Oct. 1986, pp. 811-817.
T. Ozturk, et al., "Synthesis of a Chiral Monosubstituted Derivative of Bis(ethylenedithio)tetrathiafulvalene: Reaction of the cyclic Sulfate Ester of R,R-1,4-Difluorobutane-2,3-diol ith 2-Thioxo-1,3-dithiole-4,5-dithiolate", J. Mater. Chem., 1995, 5(10), 1553-1556.
K. Vanhessche et al., "Catalytic Asymmetric Synthesis of Ne Halogenated Chiral Synthons", Chem. Eur. J. 1997, 3. No. 4.
Gao et al., "Vicinal Diol Cyclic Sulfates: Like Epoxides Only More Reactive", J. Am. Chem. Soc. 1988, 110, 7538-7539.
Albizati Kim F.
Babu Srinivasan
Borer Bennett C.
Busse Juliette K.
Remarchuk Travis P.
Agouron Phramaceuticals, Inc.
Japan Tobacco Inc.
McKane Joseph
Solola Taofiq A.
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