Methods of making antibody heavy and light chains having...

Details Methods of making antibody heavy and light chains having... Methods of making antibody heavy and light chains having...

2011-04-12

2011-04-12

Gambel, Phillip (Department: 1644)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S252100, C435S252300, C435S252330, C435S254110, C435S254210, C435S069100, C435S069700, C435S070100, C435S070210, C435S071100, C435S320100, C435S455000, C435S483000, C435S485000, C435S440000, C435S430100, C435S430100

Reexamination Certificate

active

07923221

ABSTRACT:
The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains or fragments thereof in a single cell. The invention also relates to the vectors used to produce the immunoglobulin or fragment, and to cells transformed with the vectors.

REFERENCES:
patent: 4179337 (1979-12-01), Davis
patent: 4224404 (1980-09-01), Viza et al.
patent: 4237224 (1980-12-01), Cohen
patent: 4338397 (1982-07-01), Gilbert
patent: 4342832 (1982-08-01), Goeddel et al.
patent: 4348376 (1982-09-01), Goldenberg
patent: 4366246 (1982-12-01), Riggs
patent: 4370417 (1983-01-01), Hung
patent: 4399216 (1983-08-01), Axel et al.
patent: 4403036 (1983-09-01), Hartley
patent: 4418149 (1983-11-01), Ptashne et al.
patent: 4419446 (1983-12-01), Howley et al.
patent: 4431740 (1984-02-01), Bell et al.
patent: 4440859 (1984-04-01), Rutter et al.
patent: 4444878 (1984-04-01), Paulus et al.
patent: 4495280 (1985-01-01), Bujard et al.
patent: 4500637 (1985-02-01), Neville, Jr. et al.
patent: 4510244 (1985-04-01), Parks et al.
patent: 4511502 (1985-04-01), Builder et al.
patent: 4512922 (1985-04-01), Jones et al.
patent: 4518584 (1985-05-01), Mark
patent: 4565785 (1986-01-01), Gilbert et al.
patent: 4599197 (1986-07-01), Wetzel
patent: 4634665 (1987-01-01), Axel et al.
patent: 4642334 (1987-02-01), Moore et al.
patent: 4668629 (1987-05-01), Kaplan
patent: 4704362 (1987-11-01), Itakura et al.
patent: 4713339 (1987-12-01), Levinson et al.
patent: 4766075 (1988-08-01), Goeddel et al.
patent: 4792447 (1988-12-01), Uhr et al.
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4965196 (1990-10-01), Levinson et al.
patent: 5081235 (1992-01-01), Shively et al.
patent: 5098833 (1992-03-01), Lasky et al.
patent: 5116964 (1992-05-01), Capon et al.
patent: 5137721 (1992-08-01), Dallas
patent: 5149636 (1992-09-01), Axel et al.
patent: 5179017 (1993-01-01), Axel et al.
patent: 5225538 (1993-07-01), Capon et al.
patent: 5225539 (1993-07-01), Winter
patent: 5336603 (1994-08-01), Capon et al.
patent: 5420020 (1995-05-01), Riggs
patent: 5428130 (1995-06-01), Capon et al.
patent: 5455165 (1995-10-01), Capon et al.
patent: 5500362 (1996-03-01), Robinson et al.
patent: 5514582 (1996-05-01), Capon et al.
patent: 5545403 (1996-08-01), Page
patent: 5545404 (1996-08-01), Page
patent: 5545405 (1996-08-01), Page
patent: 5561053 (1996-10-01), Crowley
patent: 5583013 (1996-12-01), Itakura et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5605689 (1997-02-01), Ammann
patent: 5612185 (1997-03-01), Uhr et al.
patent: 5648237 (1997-07-01), Carter
patent: 5686072 (1997-11-01), Uhr et al.
patent: 5721108 (1998-02-01), Robinson et al.
patent: 5736137 (1998-04-01), Anderson et al.
patent: 5807715 (1998-09-01), Morrison et al.
patent: 5840545 (1998-11-01), Moore et al.
patent: 5846818 (1998-12-01), Robinson et al.
patent: 5877293 (1999-03-01), Adair et al.
patent: 5965405 (1999-10-01), Winter et al.
patent: 5997867 (1999-12-01), Waldmann et al.
patent: 6054297 (2000-04-01), Carter et al.
patent: 6054561 (2000-04-01), Ring
patent: 6120767 (2000-09-01), Robinson et al.
patent: 6204023 (2001-03-01), Robinson et al.
patent: 6331415 (2001-12-01), Cabilly et al.
patent: 6455275 (2002-09-01), Axel et al.
patent: 6548640 (2003-04-01), Winter
patent: 6979556 (2005-12-01), Simmons et al.
patent: 194982 (1983-02-01), None
patent: 12417/83 (1983-09-01), None
patent: B-26429/84 (1984-10-01), None
patent: 46556/85 (1986-03-01), None
patent: 65981/86 (1987-05-01), None
patent: 37723 (1981-10-01), None
patent: 037723 (1981-10-01), None
patent: 041313 (1981-12-01), None
patent: 41313 (1981-12-01), None
patent: 41767 (1981-12-01), None
patent: 041767 (1981-12-01), None
patent: 044722 (1982-01-01), None
patent: 55945 (1982-07-01), None
patent: 57107 (1982-08-01), None
patent: 057107 (1982-08-01), None
patent: 060057 (1982-09-01), None
patent: 068763 (1983-01-01), None
patent: 68763 (1983-01-01), None
patent: 073656 (1983-03-01), None
patent: 73656 (1983-03-01), None
patent: 75444 (1983-03-01), None
patent: 075444 (1983-03-01), None
patent: A-073656 (1983-03-01), None
patent: 88994 (1983-09-01), None
patent: 093619 (1983-11-01), None
patent: 102634 (1984-03-01), None
patent: 0 120 694 (1984-10-01), None
patent: 120694 (1984-10-01), None
patent: 0 125 023 (1984-11-01), None
patent: 125023 (1984-11-01), None
patent: 0171 496 (1986-02-01), None
patent: 173494 (1986-03-01), None
patent: 177343 (1986-04-01), None
patent: 194276 (1986-09-01), None
patent: 196864 (1986-10-01), None
patent: 234592 (1987-09-01), None
patent: 255694 (1988-02-01), None
patent: 36776 (1988-05-01), None
patent: 324162 (1989-07-01), None
patent: 114506 (1989-11-01), None
patent: 0 365 997 (1990-05-01), None
patent: 088994 (1991-06-01), None
patent: 550400 (1993-07-01), None
patent: 481790 (1999-02-01), None
patent: 2068969 (1981-08-01), None
patent: 8308235 (1983-03-01), None
patent: 8422238 (1984-09-01), None
patent: 9022543 (1990-11-01), None
patent: 08235 (2000-05-01), None
patent: 62 201 581 (1987-09-01), None
patent: WO 81/02426 (1981-09-01), None
patent: WO 82/03088 (1982-09-01), None
patent: WO 83/00164 (1983-01-01), None
patent: WO 86/01533 (1986-03-01), None
patent: WO 87/02671 (1987-05-01), None
patent: WO 89/00999 (1989-02-01), None
patent: WO 89/01783 (1989-03-01), None
patent: WO 92/16553 (1992-10-01), None
patent: WO 93/07899 (1993-04-01), None
patent: WO 93/10817 (1993-06-01), None
patent: WO 93/21319 (1993-10-01), None
patent: 9429351 (1994-12-01), None
patent: WO 97/30087 (1997-08-01), None
patent: 8809711 (1988-06-01), None
Gillis, S.D. & J.S. Wesolowski 1990 Hum. Antibod. Hybridomas 1(1): 47-54.
Owens, R.J. & R.J. Young 1994 Journal of Immunological Methods 168:149-165.
Skerra et al 1988 Science 240: 1038-1041.
Better et al. 1989 Methods Enzymol 178: 476-496.
Taylor et al 1988 Mol Cell Biol 8(10): 4197-4203.
Letherbarrow 1985 Midec. Immuno (22(4): 407-415.
Raghunathan et al 1996 Prog. Biophy. &Mol. Biol. 65(5): 143.
Wright et al 1991 EMBO J. 10(10): 2717-2723.
Buchner et al 1991 Bio/Technology 9:157-162.
Morrison et al Adv. Immunol. (1989).
Horowitz et al. PNAS, (1988).
Skerrs et al Protein Engineering, (1991).
“Immunoglobulin molecules and genes”Microbiology Including Immunology and Molecular Genetics, Third edition, Harper International Edition vol. Chapter 17:338-379.
Accolla et al., “Monoclonal antibodies specific for carcinoembryonic antigen and produced by two hybrid cell lines”Proc. Natl. Acad. Sci. USA77(1):563-566 (1980).
Adams et al., “Molecular cloning of mouse immunoglobulin heavy chain messenger ribonucleic acids coding for μ, α, γ1, γ2a, and γ3 chains”Biochemistry19:2711-2719 (1980).
Amster et al., “Synthesis of part of a mouse immunoglobulin light chain in a bacterial clone”Nucl. Acids Res. 8(10):2055-2065 (1980).
Boss and Emtage, “Expression of an immunoglobulin light chain gene inEscherichia coli” Gene Expression—Proc. Cetus-UCLA Symposiumpp. 513-522 (Mar. 26, 1983).
Boss and Wood, “Genetically engineered antibodies”Immunology Today6 (1) : 12-13 (1985).
Colman and Morser, “Export of proteins from oocytes ofXenopus laevis” Cell17:517-526 (1979).
Colman et al., “Interactions of mouse immunoglobulin chains withinXenopus oocytes” J. Mol. Biol. 160:459-474 (1982).
Cowan et al., “Intracellular immunoglobulin chain synthesis in non-secreting variants of a mouse myeloma: detection of inactive light-chain messenger RNA”J. Mol. Biol. 90:691-701 (1974).
De Boer et al ., “Construction of a tandem trp-lac promoter and a hybrid trp-lac promoter for efficient and controlled expression of the human growth hormone gene inEscherichia coli” Promoters, Structure and Function(Praeger Publishers, R. Rodriguez and M. Chamberline

Affiliated with

Also associated with

Rating

Methods of making antibody heavy and light chains having... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of making antibody heavy and light chains having..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of making antibody heavy and light chains having... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2721816