Methods of making and using surfactant polymers

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S002600, C530S300000

Reexamination Certificate

active

10823218

ABSTRACT:
Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages. The hydrophilic side chain is selected from the group consisting of: a neutral oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged oligosaccharide, preferably a negatively charged oligosaccharide having a weight average molecular weight of less than 10,000; an oligopeptide of from about 3 to about 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a biomaterial are also provided.

REFERENCES:
patent: 5741852 (1998-04-01), Marchant et al.
patent: 5897955 (1999-04-01), Drumheller
patent: 5993890 (1999-11-01), Marchant et al.
patent: 6759388 (2004-07-01), Marchant et al.
“Biosynthetic Surfactants: Novel Biomimetic Surface Modifications for Biomedical Deposit Resistance” by Marchant et al., American Chemical Society Conference, Sep. 1997.
“Novel Nonionic Oligosaccharide Surfactant Polymers Derived from Poly(vinylamine) with Pendant Dextran and Hexanoyl Groups” by Qiu, et al., Macromolecules, 1998, 31, pp. 165-171.
“Biomimetic engineering of non-adhesive glycocalyx-like surfaces using oligosaccharide surfactant polymers” by Holland, et al. Nature, vol. 392, Apr. 23, 1998, pp. 799-801.
“Integrin-Dependent Interaction of Human Vascular Endothelial Cells on Biomimetic Peptide Surfactant Polymers” by Murugesan et al., Cell Communication and Adhesion, vol. 9, No. 2, pp. 59-73, 2002.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of making and using surfactant polymers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of making and using surfactant polymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of making and using surfactant polymers will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3901716

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.