Methods of making an antibody that binds a chemerin polypeptide

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S388100

Reexamination Certificate

active

08030453

ABSTRACT:
The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.

REFERENCES:
patent: 5948664 (1999-09-01), Williams et al.
patent: 6822072 (2004-11-01), Edwards et al.
patent: 2003/0022188 (2003-01-01), Macina et al.
patent: 2003/0096299 (2003-05-01), Wittamer et al.
patent: 2005/0084936 (2005-04-01), Lal et al.
patent: WO/00/31258 (2000-06-01), None
patent: WO 02 03789 (2002-01-01), None
Adams, et al.; “1,25 Dihydroxyvitamin D3 and Dexamethasone Induce the Cyclooxygenase 1 Gene in Osteoclast-Supporting Stromal Cells”; (1999);J. of Cellular Biochemistry; 74: 587-595.
Nagpal, et al.; “Tazarotene-induced Gene 2 (TIG2), a Novel Retinoid-Responsive Gene in Skin”; (1997);J. Invest. Dermatol.; 109: 91-95.
Samson, et al.; “ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains”; (1998);Eur. J. Immunology; 28: 1689-1700.
Methner, et al.; “A Novel G Protein-Coupled Receptor with Homology to Neuropeptide and Chemoattractant Receptors Expressed during Bone Development”; (1997);Biochemical and Biophysical Research Communications; 233: 336-342.
Kotani, M., M. Detheux, A. Vandengogaerde, D. Communi, J.M. Vanderwinden, E. Le Poul, S. Brezillon, R. Tyldesley, N. Suarez-Huerta, F. Vandeput, C. Banpain, S.N. Schiffmann, G. Vassart, and M. Parmentier, “The metastasis-suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54”, (2001),J.Biol.Chem. 276:34631-34636.
Joost, P., and A. Methner, “Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands”, (2002),Genome Biology3, 0063.1-0063.16.
Lee, D.K., S.R. George, J.F. Evans, K.R. Lynch, and B.F. O'Dowd, “Orphan G protein-coupled receptors in the CNS”, (2001),Curr. Opin. Pharacol. 1:31-39.
Im, D.S., “Orphan G protein-coupled receptors and beyond”, (2002),Jpn. J. Pharmacol. 90:101-106.
Owman, C. et al. Molecular Cloning and Tissue Distribution of cDNA encoding a novel chemoattractant-like receptor, Biochemical and Biophysical Research Communiications, 241(2):390-394 (Dec. 18, 1997).
Gantz et al., Moleular Cloning of a Novel Receptor (cmklr1) With Homology to the Chemotactic Factor Receptors, Cytogenetics and Cell Genetics, vol. 74, pp. 286-290 (1996).
Zabel et al., Chemoattractants, Extracellular Proteases, and the Integrated Host Defense Response, Experimental Hematology, vol. 34, pp. 1021-1032 (2006).
Duvic et al., Molecular Mechanisms of Tazarotene Action in Psoriasis, J. Am. Adac. Dermatol., vol. 37, pp. S18-24, Aug. 1997.
Communi et al. “Receptors responsive to extracellular pyrimidine nucleotides” Trends in Pharmacological Sciences 18(3):83-86, Mar. 1, 1997.
Communi et al. “Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenyl cyclase”, J. Biol. Chem. 272(51):31969-31973.
Wittamer et al. “Specific Recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids”, Journal of Experimental Medicine, Oct. 6, 2003, 198:No. 7: p. 977-985.
Wittamer et al. “The C-terminal nanopeptide of mature chemerin activates the chemerin receptor with low nanomolar potency”, J. of Biological Chemistry, Mar. 12, 2004, 279 (No. 11):9956-9962.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of making an antibody that binds a chemerin polypeptide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of making an antibody that binds a chemerin polypeptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of making an antibody that binds a chemerin polypeptide will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4270571

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.