Liquid purification or separation – Processes – Liquid/liquid solvent or colloidal extraction or diffusing...
Reexamination Certificate
2001-05-25
2003-01-14
Vollano, Jean F. (Department: 1621)
Liquid purification or separation
Processes
Liquid/liquid solvent or colloidal extraction or diffusing...
C210S650000, C210S652000
Reexamination Certificate
active
06506305
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to methods for readily isolating urea from a solution containing urea using membrane isolation technology. By using isolating methods of the present invention, urea can be readily isolated and recovered, for example, from natural products, and also urea can be readily isolated and removed from sewage.
Further, the present invention relates to compositions containing milk-derived urea and to methods for producing the same. The compositions containing milk-derived urea of the present invention can be readily isolated and recovered from milk or milk materials by using membrane isolating technology, and can be used as urea materials derived from natural products.
Isolation using membranes first started with the use of an RO membrane to convert seawater to freshwater. Until today, various membranes have been used in different fields. Use of membranes in a dairy industry started with the isolation of whey proteins from whey using an ultra filtration (UF) membrane. Today, all the membranes, i.e., an NF membrane, RO membrane, UF membrane, and microfiltration (MF) membrane are used.
2. Description of the Related Art
Urea, a compound expressed by a chemical formula CO(NH
2
)
2
, was discovered by F. M. Rouelle in 1773, and the first organic compound that was successfully synthesized by F. Wohler in 1828. Since then, various methods of synthesizing urea have been proposed. Today, urea is synthesized by the direct method using ammonia and carbon dioxide as starting materials. Urea thus obtained is manufactured on a large scale, and used as an industrial raw material for products, such as urea resins, or as raw materials for chemical fertilizers, medicines and the like.
Urea is a final nitrogenous decomposition product of amino acids, nucleic acid bases and the like, and found in the blood and body fluids of vertebrates, and the urine of mammals. Urea is also found in nematodes, arthropods, mollusks, mushrooms, molds and the like. It is known that urea is present in the muscle of mollusks, such as sharks, in an amount of more than 1%, and also in the human blood in an amount of 0.02 to 0.03%. Urea is used as a raw material in agricultural chemicals, chemically synthesized products, medicines and the like. Furthermore, urea is admixed into hand creams or skin care creams to provide a moisturizing effect, or used as an effective component in diuretics.
Until now, no method of readily isolating and recovering urea from natural products has been reported. Thus, urea derived from natural products is not effectively used, and only synthesized urea is used.
On the other hand, the level of urea present in sewage is publicly regulated along with ammonia. The concentrations of ammonia and urea in sewage have to be less than 100 ppm. Accordingly, improved sewage treatment is needed. Proposed methods for removing urea today are hydrolyzation of urea into ammonia and carbon dioxide, and reaction of urea with nitrifying bacteria. However, these methods involve extremely complicated steps, such as heating at a high temperature or the use of microorganisms. Thus, it is currently difficult to satisfy these standards for sewage. Accordingly, development of methods of readily isolating and recovering urea from natural products, or readily isolating and removing urea from sewage is in great need.
Furthermore, there is a need to produce urea-containing compositions derived from natural products, which can be used in manufacturing products, such as cosmetics and medicines, where safety is a concern.
SUMMARY OF THE INVENTION
The present inventors intensively studied the development of methods of readily isolating and recovering urea from natural products with the view of effectively utilizing urea of natural origin. As a result, the present inventors found that urea actually permeates a nanofiltration (NF) membrane and reverse osmotic (RO) membrane, which were said to be permeable only to water and salts. Thus, the present inventors found that urea can be brought into the permeate side by treating a urea-containing fraction extracted from natural products or sewage containing urea, with an NF membrane or RO membrane.
Furthermore, the present inventors found that a milk-derived composition containing urea at a level of more than 0.2% of the total solids can be obtained by treating natural products such as milk or milk materials with an NF membrane or RO membrane to bring a fraction containing urea into the permeate side. The present inventors then found that the milk-derived urea-containing composition can be used as a highly safe urea material of natural origin in manufacturing hand creams, diuretics and the like, and completed the present invention.
Accordingly, the present invention provides methods of readily isolating and recovering urea, which can be used as a raw material in cosmetics, medicines, fertilizers, and the like, from natural products, and methods of readily isolating and removing urea from sewage in the process of sewage treatment.
Furthermore, the present invention provides methods of producing a milk-derived urea-containing composition which can be used as a urea material of natural origin, by recovering the permeate by treating milk or milk materials with an NF membrane or RO membrane.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
In the present invention, an NF membrane or RO membrane is used to isolate urea from solutions containing urea. Further, in the present invention, an NF membrane or RO membrane is used to produce compositions containing milk-derived urea. Unlike an ultrafiltration (UF) membrane or microfiltration (MF) membrane, an NF membrane or RO membrane used in the present invention has no micro pores on the membrane surface. Thus, the mechanism for the permeability of an NF membrane or RO membrane has not been revealed, and it is today difficult to theoretically explain why urea, which has been known not to permeate an NF membrane or RO membrane, can permeate these membranes. One theory is the intramembrane dissolution and dispersion theory that certain substances dissolve and disperse within a membrane while permeating. This intramembrane dissolution and dispersion theory may well explain why urea permeates an NF membrane or RO membrane. Namely, urea is considered to readily dissolve in an NF membrane or RO membrane.
Examples of RO membranes to be used in the present invention include Dasal-3 Desalination), HR-95 (Dow Danmark), and NTR-729HF (Nitto Denko). Examples of NF membranes include Desal-5 (Desalination), NF-45 (Dow Danmark), and NTR-7450(Nitto Denko). The shape of membranes to be used is not restricted, and can be selected depending on the solutions to be treated. If sanitary conditions are required, a spiral membrane is desirable. If solutions to be treated are highly viscous or contain large particles, a hollow fiber membrane is not suitable, and a spiral membrane is appropriately used.
A treatment temperature between 5 C. and 60 C. is desirable for treatment of solutions containing urea with an NF membrane or RO membrane. Urea could be decomposed at a temperature higher than 60 C. Treatment efficiency decreases at a temperature below 5 C. Other conditions such as the pressure and flow rate for the treatment can be the same as those ordinarily used in NF membrane or RO membrane treatment.
Thus, solutions containing urea can be treated with an NF membrane or RO membrane to bring the urea into the permeate side for isolation, then the isolated urea can be recovered or removed as required.
Further, in the present invention, milk or milk materials are treated with an NF membrane or RO membrane to bring urea-containing compositions into the permeate side, then these milk-derived urea-containing compositions are recovered, and, if necessary, concentrated or dried by ordinary methods. If the salt concentration of solutions containing urea is high, the salt concentration of the permeate also becomes high. Therefore, it is desirable to lower the salt concentration of the urea-containing so
Kotani Masanori
Morita Minoru
Motsuchi Wataru
Serizawa Atsushi
Yamamoto Haruyoshi
Knobbe Martens Olson & Bear LLP
Snow Brand Milk Products Co. Ltd.
Vollano Jean F.
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