Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1994-10-13
1997-10-21
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4241851, 4241931, 4242481, 424 9371, 435 693, 514 2, 514 23, 530300, 530350, 530395, 530403, A61K 3904, C07K 14705
Patent
active
056793472
ABSTRACT:
The present invention is based on the observation that CD1 functions to present foreign and autoimmune antigens to a select subpopulation of T-cells. Based on this observation, the present invention provides methods for detecting the presence of a CD1-presented antigen in a sample, methods for purifying CD1-presented antigens, vaccines containing CD1-presented antigens, methods of blocking CD1 antigen presentation, methods of identifying and/or isolating CD1 blocking agents, methods of inducing CD1 expression, and T-cell lines for use in the methods disclosed herein. The CD1-presented antigens of the invention, unlike MHC-presented antigens, are non-polypeptide hydrophobic antigens. In particular, a CD1-presented antigen isolated from several mycobacterial species is a mycolic acid (MA).
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Bekierkunst, B., et al
Beckman Evan M.
Brenner Michael B.
Porcelli Steven A.
Brigham and Women's Hospital
Cunningham Thomas M.
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