Methods of isolating amyloid-inhibiting compounds and use of...

Details Methods of isolating amyloid-inhibiting compounds and use of... Methods of isolating amyloid-inhibiting compounds and use of...

2007-10-23

2007-10-23

Tate, Christopher R. (Department: 1655)

Drug, bio-affecting and body treating compositions

Plant material or plant extract of undetermined constitution...

C424S769000, C514S456000

Reexamination Certificate

active

10624436

ABSTRACT:
Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, orUncaria tomentos. These components appear to account for the majority of the amyloid or Aβ fibrillogenesis inhibitory activity. Individual fractions and/or compounds as isolated by HPLC are tested in relevant in vitro and/or animal models, and found to consistently demonstrate inhibition of amyloid or Aβ fibrillogenesis. Related extraction methods are disclosed.

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C. Wirth and H. Wagner, “Pharmacologically active Procyanidines from the bank ofUncaria tomentosa,” Phytomedicine, vol. 4 (3), pp. 265-266.

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