Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2005-08-16
2005-08-16
Tate, Christopher R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
C424S769000, C514S456000
Reexamination Certificate
active
06929808
ABSTRACT:
Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, orUncaria tomentos. These components appear to account for the majority of the amyloid or Aβ fibrillogenesis inhibitory activity. Individual fractions and/or compounds as isolated by HPLC are tested in relevant in vitro and/or animal models, and found to consistently demonstrate inhibition of amyloid or Aβ fibrillogenesis. Related extraction methods are disclosed.
REFERENCES:
patent: 4698360 (1987-10-01), Masquelier
patent: 6264994 (2001-07-01), Castillo et al.
patent: 6346280 (2002-02-01), Castillo et al.
patent: 6509381 (2003-01-01), Empie et al.
patent: 6607758 (2003-08-01), Castillo et al.
patent: 19627344 (1998-01-01), None
patent: 04145048 (1992-05-01), None
patent: 04145049 (1992-05-01), None
patent: WO 98/51302 (1998-11-01), None
patent: WO-9851302 (1998-11-01), None
patent: WO 00/02571 (2000-01-01), None
patent: WO 00/57707 (2000-10-01), None
Sigma Chemical Co. Catalog. 1994. p. 244—Product C3878, Chlorogenic acid.
Aldrich Chemical Co. Catalog. 1990/1991. p. 297—Product C 4,420-6, Chlorogenic acid.
C. Wirth and H. Wagner, “Pharmacologically active Procyanidines from the bank ofUncaria tomentosa,” Phytomedicine, vol. 4 (3), pp. 265-266.
Castillo Gerardo
Choi Paula Y.
Nguyen Elizabeth
Snow Alan D.
Dwyer Patrick M.
ProteoTech, Inc.
Tate Christopher R.
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