Methods of inhibition using glycosyl sulfotransferase-3

Details Methods of inhibition using glycosyl sulfotransferase-3 Methods of inhibition using glycosyl sulfotransferase-3

2005-01-18

2005-01-18

Moran, Marjorie (Department: 1631)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S015000, C530S408000, C536S023200

Reexamination Certificate

active

06844175

ABSTRACT:
A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-3 or KSGal6ST, or homologues thereof

REFERENCES:
patent: 5185326 (1993-02-01), Muller et al.
patent: 5227369 (1993-07-01), Rosen et al.
patent: 5318890 (1994-06-01), Rosen et al.
patent: 5580862 (1996-12-01), Rosen et al.
patent: 5695752 (1997-12-01), Rosen et al.
patent: 0 821 066 (1998-01-01), None
Lifeseq clone # 2617407.
Lifeseq clone # 2620445.
Baumhueter, Susanne, et al., “Binding of L-Selectin to the Vascular Sialomucin CD34,”Science(Oct. 15, 1993) vol. 262:436-438.
Bertozzi, Carolyn, et al., “Sulfated Dissacharide Inhibitors of L-Selectin: Deriving Structural Leads from a Physiological Selectin Ligand,”Biochemistry(1995) vol. 34, No. (44):14271-14278.
Boukerche, Habib, et al., “A Monoclonal Antibody Directed Against A Granule Membrane Glycoprotein (GMP-140/PADGEM, P-Selcetin, CD62P) Inhibits Ristocetin-Induced Platelet Aggregation,”British Journal of Haemathology(1996) vol. 92:442-451.
Celi, Alessandro, et al., “Platelet-Leukocyte-Endothelial Cell Interaction On The Blood Vessel Wall,”Seminars in Hematology(Oct. 1997) vol. 34, No. (4):327-335.
Crommie, Deidre, et al., “Biosynthesis of GlyCAM-1, a Mucin-Like Ligand for L-Selectin, ”The Journal of Biological Chemistry(Sep. 22, 1995) vol. 270, No. (38) :22614-22624.
Fukuta, Masakazu, et al., “Molecular Cloning and Expression of Chick Chondrocyte Chondroitin 6-Sulfotransferase,”The Journal of Biological Chemistry(1995) vol. 270, No. (31):18575-18580.
Fukuta, Masakazu et al., “Molecular Cloning and Characterization of Human Keratan Sulfate Gal-6-Sulfotransferase,”The Journal of Biological Chemistry(1997) vol. 272 (51):32321-32328.
Frenette, Paul S., et al., “Platelets Roll on Stimulated Endothelium In Vivo: An Interaction Mediated By Endothelial P-Selectin,”Proc. Natl. Acad. Sci.(Aug. 1995) vol. 92:7450-7454.
Girard, Jean-Philippe, et al., “High Endothelial Venules (HEVs): Specialized Endothelium For Lymphocyte Migration,”Immunology Today(1995) vol. 16, No. (9):449-457.
Habuchi, Osami, et al., “Sulfation of Sialyl Lactosamine Oligosaccharides By Chrondroitin 6-Sulfotransferase,”Gycobiology(1997) vol. 7, No. (3):405-412.
Habuchi, Osami, et al., “Enzymatic Sulfation of Galactose Residue of Keratan Sulfate By Chrondroitin 6-Sulfotransferase,”Glycobiology(1996) vol. 6, No. (1):51-57.
Habachi, Osami, et al., “Purification of Chondroitin 6-Sulfotransferase Secreted from Cultured Chick Embryo Chrondrocytes,”The Journal of Biological Chemistry(Oct. 15, 1993) vol. 268, No. (29):21968-21974.
Habuchi, Hiroko, et al., “Molecular Characterization and Expression of Heparan-Sulfate 6-Sulfotransferase,”The Journal Biological Chemistry(Apr. 10, 1998) vol. 273, No. (15):9208-9213.
Hemmerich, Stefan, et al., “Structure of the O-Glycans in GlyCAM-1, An Endothelial-Derived Ligand for L-Selectin,”The Journal of Biological Chemistry(May 19, 1995) vol. 270, No. (20):12035-12047.
Hemmerich, Stefan, et al., “Sulfation-Dependent Recognition of High Endothelial Venules (HEV)-Ligands by L-Selectin and MECA 79, An Adhesion-Blocking Monoclonal Antibody,”The Journal of Experimental medicine(Dec. 1994) vol. 180:2219-2226.
Hemmerich, Stefan, et al., “6′-Sulfated Sialyl Lewis x Is a Major capping Group of GlyCAM-1,”Biochemistry(1994) vol. 33, No. (16):4830-4835.
Hemmerich, Stefan, et al., “Identification of the Sulfated monosaccharides of GlyCAM-1, and Endothelial-Derived Ligand for L-Selectin,”Biochemistry(1994) vol. 33, No. (16):4820-4829.
Hooper, Lora V., et al., “From Legumes to Leukocytes:Biological Roles For Sulfated Carbohydrates,”The FASEB Journal(Aug. 1996) vol. 10:1137-1146.
Hillier, Marra M., et al., “The WashU-HHMI Mouse EST Project,”Nucleotide Query(1996) Accession No. AA522184.
Koenig, Andrea, et al., “Selectin Inhibition: Synthesis and Evaluation of Novel Sialylated, Sulfated and Fucosylated Oligosaccharides, Including The Major Capping Group of GlyCAM-1,”Glycobiology(1997) vol. 7, No. (1):79-93.
Lasky, Lawrence A., et al., “An Endothelial Ligand for L-Selectin Is a Novel Mucin-Like Molecule,”Cell(Jun. 12, 1992) vol. 69:927-938.
Mitsuoka, Chikako, et al., “Identification of a Major Carbohydrate Capping Group of the L-Selectin Ligand on High Endothelial Venules in Human Lymph Nodes as 6-Sulfo Sialyl Lewis X*,”The Journal of Biological Chemistry(May 1, 1998) vol. 273, No. (18):11225-11233.
Rosen, Steven D., et al., “The Selectins and their Ligands,”Current Opinion in Cell Biology(1994) vol. 6:663-673.
Sawada, Mikiko, et al., “Specific Expression of a Complex Sialyl Lewis X Antigen on High Endothelial Venules of Human Lymph Nodes: Possible Candidate for L-Selectin Ligand,”Biochemical and Biophysical Research Communications(1993) vol. 1993, No. (1):337-347.
Spiro, Robert G., et al., “Characterization of a Spleen Sulphotransferase Responsibile for the 6-O-Sulphation of the Galactose Residue in Sialyl-N-Acetyl-Lactosamine Sequences,”Biochem J.(1998) vol. 331-265-271.
Tsuboi, Shigeru, et al., “6′-Sulfo Sialyl Lexbut Not 6-Sulfo Sialyl LezExpressed on the Cell Surface Supports L-Selectin-Mediated Adhesion,”The Journal of Biological Chemistry(Nov. 1, 1996) vol. 271, No. (44):27213-27216.
Yoshino, Kochichiro, et al., “Studies on Selectin Blockers. 4. Structure-Function Relationship of Sulfated Sialyl Lewis X Hexasaccharide Ceramides Toward E-, P-, and L-Selectin Binding,”J. Med. Chem.(1997) vol. 40:455-462.

Affiliated with

Also associated with

Rating

Methods of inhibition using glycosyl sulfotransferase-3 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of inhibition using glycosyl sulfotransferase-3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of inhibition using glycosyl sulfotransferase-3 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3417671