Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Patent
1994-01-21
1997-10-14
Clardy, S. Mark
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
514 90, 514392, A61K 3324, A61K 3135, A61K 31415, A61K 3165
Patent
active
056769784
ABSTRACT:
The present invention provides for the use of creatine compounds and hyperplastic inhibitory agents for prophylactic and/or therapeutic treatments of undesirable cell growth, e.g. tumors. The present invention provides methods of using creatine compounds, in combination with a hyperplastic inhibitory agent, to inhibit the growth of undesirable cells in a subject. The present invention is based, at least in part, on the discovery that creatine compounds and hyperplastic inhibitory agents, such as inhibitory agents, additively and synergistically combine to inhibit cell growth. The present invention further pertains to compositions for inhibiting undesirable cell growth in a subject. The compositions of the present invention include an effective amount of the creatine compound and a hyperplastic inhibitory agent in a pharmaceutically acceptable carrier. Other aspects of the invention include packaged creatine compounds and inhibitory agents. The packaged compounds and agents also include instructions for using the creatine compound/inhibitory agent combination for inhibiting undesirable cell growth in a patient or instructions for using the compounds and agents, in selected quantities, in a pharmaceutically acceptable carrier.
REFERENCES:
patent: 4766149 (1988-08-01), Osswald et al.
patent: 5321030 (1994-06-01), Kaddurah-Daouk et al.
patent: 5324731 (1994-06-01), Kaddurah-Daouk et al.
Bergmann et al. . "Synthese des Kreatines aus Sarkosin und Arginin--Neue Synthese des Methylguanidins", Z. Physiol. Chem. 173, 80-83 (1928).
Rowley et al. "On the Specificity of Creatine Kinase, New Glycocyamines and Glycocyamine Analogs Related to Creatine", J. Am. Chem., 247:5542-5551 (Oct. 1971).
McLaughlin et al., "Specificity of Creatine Kinase for Guanidino Substrates", J. Biol. Chem., 247:4382-4388 (Jul. 1972).
Wang, T., "Synthesis and Properties of N-Acetimidoyl Derivatives of Glycine and Sarcosine", J. Org. Chem, 39:3591-3594 (1974).
G.R. Griffiths et al., "Accumulation of Analog of Phosphocreatine in Muscle of Chicks Fed 1-Carboxymethyl-2-iminoimidazolidine (Cyclocreatine)", J. Biol. Chem., 251:2049-2054 (Apr. 1976).
T.M. Annesley et al., "Cyclocreatine Phosphate as a Substitute for Creatine Phosphate in Vertebrate Tissues. Energetic Considerations", Biochem. Biophys. Res. Commun., 74:185-190 (1977).
M.C. Berenbaum, "Synergy, Additivism and Antagonism in Immunosuppression", A Critical Review., Clin. Exp. Immunol., 28:1-18 (1977).
D.F. Deen et al., "Isobologram Analysis of X-Ray-BCNU Interactions In Vitro", Radiat. Res., 79:483-491 (1979).
J.B. Walker, "Creatine: Biosynthesis, Regulation, and Function", Adv. Enzymol., 50:177-241 (1979).
Lowe et al., "Evidence for an Associative Mechanism in the Phosphoryl Transfer Step Catalyzed by Rabbit Muscle Creatine Kinase", J. Biol. Chem., 225:3944-3951 (May 1980).
Summerhayes et al., "Unusual Retention of Rhodamine 123 by Mitochondria in Muscle and Carcinoma Cells", Proc. Natl. Acad. Sci. USA, 79: 5292-5296 (Sep. 1982).
Roberts et al., "Synthesis and Accumulation of an Extremely Stable High-Energy Phosphate Compound by Muscle, Heart, and Brain of Animals Fed the Creatine Analog, 1-Carboxyethyl-2-iminoimidazolidine (Homocyclocreatine)" Arch. Biochem. Biophys., 220:563-571 (Feb. 1983).
D.N. Carney et al., "Elevated Serum Creatine Kinase BB Levels in Patients with Small Cell Lung Cancer", Cancer Res., 44:5399-5403 (Nov. 1984).
L.C. Mahadevan et al., "The Brain Isoform of a Key ATP-Regulating Enzyme, Creatine Kinase, is a Phosphoprotein", Biochem., 222:139-144 (1984).
Roberts et al., "Higher Homolog and N-Ethyl Analog of Creatine as Synthetic Phosphagen Precursors in Brain, Heart, and Muscle, Repressors of Liver Amidinotransferase, and Substrates for Creatine Catabolic Enzymes", J. Biol. Chem., 260:13502-13508 (Nov. 1985).
B.A. Teicher et al., "Alkylating Agents: In Vitro Studies of Cross-Resistance Patterns", Cancer Res., 46:4379-4383 (Sep. 1986).
B.A. Teicher et al., "Characterization of a Human Squamous Carcinoma Cell Line Resistant to Cis-Diamminedichloroplatinum(II)", Cancer Res., 47:388-393 (Jan. 1987).
B.A. Teicher et al., "Combination of N,N',N"-Triethylenethiophosphoramide and Cyclophosphamide In Vitro and In Vivo", Cancer Res., 48:94-100 (Jan. 1988).
S. Becker et al., "Investigations on the Function of Creatine Kinase in Ehrlich Ascites Tumor Cells", Biol. Chem. Hoppe-Seyler, 370:357-364 (Apr. 1989).
K. Chida et al., "Purification and Identification of Creatine Phosphokinase B as a Substrate of Protein Kinase C in Mouse Skin In Vivo", Biochem. Biophys. Res. Commun., 173:351-357 (Nov. 1990).
A.F.G. Quest et al., "Phosphorylation of Chicken Brain-Type Creatine Kinase Affects a Physiologically Important Kinetic Parameter and Gives Rise to Protein Microheterogeneity In Vivo", FEBS Lett., 269:457-464 (Sep. 1990).
Y. Ohira et al., "Reduced Growth of Ehrlich Ascites Tumor Cells in Creatine Depleted Mice Fed .beta.-Guanidinopropionic Acid", Biochim. Biophys. Acta, 1097:117-122 (1991).
B.A. Teicher et al., "Characteristics of Five Human Tumor Cell lines and Sublines Resistant to Cis-Diamminedichloroplatinum(II)", Int. J. Cancer, 47:252-260 (1991).
B.A. Teicher et al., "Chemotherapeutic Potentiation Through Interaction at the Level of DNA", In: Synergism and Antagonism in Chemotherapy, Academic Press, New York, pp. 541-583, T.C. Chow and D.C. Rideout, Ed. (1991).
T. Walliman et al., "Intracellular Compartmentation, Structure and Function of Creatine Kinase Isoenzymes in Tissues with High and Fluctuating Energy Demands: The `Phosphocreatine Circuit` for Cellular Energy Homeostasis", Biochem. J., 281:21-40 (1992).
J.W. Lillie et al., "Cyclocreatine (1-Carboxymethyl-2-iminoimidazolidine) Inhibits Growth of a Broad Spectrum of Cancer Cells Derived from Solid Tumors", Cancer Res., 53:3172-3178 (Jul. 1993).
E.E. Miller et al., "Inhibition of Rate of Tumor Growth by Creatine and Cyclocreatine", Proc. Nat. Acad. Sci. U.S.A., 90:3304-3308 (Apr. 1993).
Kaddurah-Daouk Rima
Kufe Donald W.
Teicher Beverly A.
Amira, Inc.
Clardy S. Mark
Dana-Farber Cancer Institute
Hanley Elizabeth A.
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