Methods of inhibiting the PSGL-1-mediated adhesion and...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S130100, C424S133100, C424S141100, C424S143100, C424S144100, C424S152100, C424S153100, C424S172100, C424S173100, C530S387100, C530S387300, C530S388100, C530S388200, C530S388220, C530S388700, C530S388730, C530S388750

Reexamination Certificate

active

07833530

ABSTRACT:
The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both selectin and chemokine binding to PSGL-1 expressed on leukocytes, lymphocytes and endothelial cells and thus which inhibit migration and/or rolling of these cells and to methods for screening for such antibodies and binding fragments thereof and to methods of therapeutic use thereof.

REFERENCES:
patent: 5667988 (1997-09-01), Barbas et al.
patent: 7744888 (2010-06-01), Lin et al.
patent: 2002/0031508 (2002-03-01), Wagner et al.
patent: 2002/0086014 (2002-07-01), Korman et al.
patent: 2003/0018181 (2003-01-01), Larsen et al.
patent: 2004/0001839 (2004-01-01), Levanon et al.
patent: 2004/0002450 (2004-01-01), Lazarovits et al.
patent: 2004/0214272 (2004-10-01), La Rosa et al.
patent: 2005/0069955 (2005-03-01), Plaksin et al.
patent: 2006/0286112 (2006-12-01), Kellermann et al.
patent: 2007/0020624 (2007-01-01), Rubenfield et al.
patent: 2007/0160601 (2007-07-01), Widom et al.
patent: 2008/0019984 (2008-01-01), Shusta et al.
Hirata et al., “Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus,”J. Biol. Chem., (Issue of Dec. 10, 2004) vol. 279, No. 50, pp. 51775-51782.
Inoue, et al., “Blockade of PSGL-1 attenuates DC14+ monocytic cell recruitment in Intestinal mucosa and ameliorates ileitis in SAMP1/Yit mice,”Journal of Leukocyte Biology, (Mar. 2005) vol. 77, pp. 287-295.
Li et al., “Visualization of P-selectin Glycoprotein Ligand-1 as a Highly Extended Molecule and Mapping of Protein Epitopes for Monoclonal Antibodies,”The Journal of Biological Chemistry, vol. 271, No. 11, (Issue of Mar. 15, 1996) pp. 6342-6348.
Marini et al., “TNF-α neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis,”PNAS, vol. 100, No. 14, (Jul. 8, 2003) pp. 8366-8371.
Moore et al., “P-Selectin Glycoprotein Ligand-1 Mediates Rolling of Human Neutorphils on P-Selectin,”J. Cell. Biol., vol. 128, No. 4 (Feb. 1995) pp. 661-671.
Rivera-Nieves et al., “Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis”,The Journal of Experimental Medicine, vol, 203, No, 4, (Apr. 17, 2006) pp, 907-917.
Swers, “Isolation and Engineering of a High Affinity Antibody Against P-selectin Glycoprotein Ligand-1 (PSGL-1),” Ph.D. Thesis,Department of Engineering at Massachusetts Institute of Technology, (Feb. 18, 2005) pp. 1-96.
Swers et al., “A high affinity human antibody antagonist of P-selectin mediated rolling,”Biochemical and Biophysical Research Communications, vol. 350, (Aug. 12, 2006) pp. 508-513.
Thatte et al., “Binding of function-blocking mAbs to mouse and human P-selectin glycoprotein ligand-1 peptides with and without tyrosine sulfation,”Journal of Leukocyte Biology, vol. 72, (Sep. 2002) pp. 470-477.
Veerman et al., “Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs,”Nature Immunology, vol, 8, No. 5 (May 2007) pp. 532-539.
PCT Search Report, PCT/US2009/044188, Dec. 4, 2009.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of inhibiting the PSGL-1-mediated adhesion and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of inhibiting the PSGL-1-mediated adhesion and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of inhibiting the PSGL-1-mediated adhesion and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4248370

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.