Methods of inhibiting phosphatase activity and treatment of diso

Details Methods of inhibiting phosphatase activity and treatment of diso Methods of inhibiting phosphatase activity and treatment of diso

1996-01-22

1997-03-25

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31192

Patent

active

056146426

ABSTRACT:
The present invention relates to organic molecules capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such molecules to modulate or regulate signal transduction by inhibiting protein tyrosine phosphatase activity. Finally, the invention relates to the use of such molecules to treat various disease states including diabetes mellitus.

REFERENCES:
patent: 4324728 (1982-04-01), Omura et al.
patent: 4904590 (1990-02-01), Fukuda et al.
patent: 5081264 (1992-01-01), Toki et al.
patent: 5155031 (1992-10-01), Posner et al.
Taniguchi, Science, 268, 251-255 May 1995.
Pawson, Nature, 373, 573-80 Feb. 1995.
Cohen et al., Cell, 80, 237-48 Jan. 1995.
Heldin, Cell, 80, 213-23 Jan. 1995.
Xiao et al., J. Biol Chem., 269, 21244-21248 Aug. 1994.
Schlessinger et al., Curr. Opin. Genet. Dev., 4, 25-30 Feb. 1994.
Darnell et al., Science, 264, 1415-1421 Jun. 1994.
Millauer et al., Nature, 367, 576-79 Feb. 1994.
Mauro and Dixon, Trends Biochem. Sci., 19, 151-55 Oct. 1994.
Burke et al., Biochem. Biophys. Res. Comm., 204, 129-134 Oct. 1994.
den Hertog et al., EMBO J., 12, 3789-98 Jun. 1993.
Schultz et al., Cell, 73, 1445-54 Jul. 1993.
Jiang et al., Mol. Cell. Biol., 13, 2942-51 May 1993.
Vogel et al., Science, 259, 1611-14 Mar. 1993.
Sadowski et al., Science, 261, 1739-44 Aug. 1993.
Yan et al., J. Biol. Chem., 268, 24880-24886 Nov. 1993.
Goldstein, J. Cell. Biochem., 48, 33-42 Mar. 1992.
Hedge et al., J. Antibiotics, 46, 207-13 Feb. 1993.
Pot and Dixon, Biochem. Biophys. Acta, 1136, 35-43 Aug. 1992.
Zheng et al., Nature, 359, 336-39 Sep. 1992.
Spivak et al., Exp. Hematol., 20, 500-504 Oct. 1992.
Saito and Streuli, Cell Growth Differ., 2, 59-65 Jan. 1991.
Fischer et al., Science, 253, 410-406 Jul. 1991.
Shen et al., Nature, 352, 736-39 Aug. 1991.
Kaplan et al., Proc. Natl. Acad. Sci., 87, 7000-7004 Sep. 1990.
Lund et al., Nature, 345, 727-29 Jun. 1990.
Cool et al., Proc. Natl. Acad. Sci., 86, 5257-61 Jul. 1989.
Solomon et al., Am. J. Med. Sci., 297, 372-76 Jun. 1989.
Charbonneau et al., Proc. Natl. Acad. Sci., 86, 5252-56 Jul. 1989.
Charbonneau et al., Proc. Natl. Acad. Sci., 85, 7182-86 Oct. 1988.
Suganuma et al., Proc. Natl. Acad. Sci., 85, 1768-71 Mar. 1988.
Slamon et al., Science, 235, 177-82 Jan. 1987.
Dubyak and Kleinzeller, J. Biol. Chem., 255, 5306-12 Jun. 1980.
Shechter and Karlish, Nature, 284, 556-58 Apr. 1980.

Affiliated with

Also associated with

Rating

Methods of inhibiting phosphatase activity and treatment of diso does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of inhibiting phosphatase activity and treatment of diso, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of inhibiting phosphatase activity and treatment of diso will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2204662