Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1997-02-11
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549389, A61K 3135, C07D30932
Patent
active
056021712
ABSTRACT:
The present invention relates to organic molecules capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such molecules to modulate or regulate signal transduction by inhibiting protein tyrosine phosphatase activity. Finally, the invention relates to the use of such molecules to treat various disease states including diabetes mellitus.
REFERENCES:
patent: 5155031 (1992-10-01), Posner et al.
Taniguchi, 1995, "Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases", Science 268:251-255.
Pawson, 1995, "Protein Modules and Signalling Networks", Nature 373:573-580.
Cohen et al., 1995, "Modular Binding Domains in Signal Transduction Proteins", Cell 80:237-248.
Heldin, 1995, "Dimerization of Cell Surface Receptors in Signal Transduction", Cell 80:213-223.
Xiao et al., 1994, "Syp (SH-PTP2) is a Positive Mediator of growth Factor-stimulated Minogenic Signal Trtansduction", J Biol Chem 269:21244-21248.
Schlessinger et al., 1994, "SH2/SH3 Signalling Proteins", Curr Opin Genet Dev 4:25-30.
Darnell et al., 1994, "Jak-STAT Pathways and Transcriptional Activation in Responce to IFNs and Other Extracellular Signalling Proteins", Science 264:1415-1421.
Millauer et al., 1994 "Globlastoma Growth Inhibited In Vivo By a Dominant-Negative Flk-1 Mutant", Nature 367:576-579.
Mauro and Dixon, 1994, "Zip Codes 'Direct Intracellular Protein Tyrosine Phosphatases to the Correct Cellular `Address`", Trends Biochem sci 19:151-155.
Burke et al., 1994, "Potent Inhibition of Insulin Receptor Dephosphorylation By a Hexamer Peptide Containing the Phosphotyrosyl Mimetic F.sub.2 Pmp", Biochem Biophys Res Comm 204:129-134.
den Hertog et al., 1993, "Receptor Protein Tyrosine Phosphatase .alpha. Activates pp620.sup.c-src and is Involved in Neuronal Differentiation", EMBO J 12:3789-3798.
Schultz et al., 1993, "Mutations at the Murine Motheaten Locus Are Withiin Locus Are Within the Hematopoietic Cell Protein-Tyrosine Phosphatase (Hcph) Gene", Cell 73:1445-1454.
Jiang et al., 1993, "Cloning and Characterization of R-PTP-k, a New Member of the Receptor Protein Tyrosine Phosphatase Family with a Proteolytically Cleaved Adhesion Molecule-Like Extracellular Region", Moll Cell Biol 13:2942-2951.
Vogel et al., 1993, "Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation", Science 259:1611-1614.
Sadowski et al., 1993, "A Common Nuclear Signal Transuction Pathway Activated By Growth Factor and Cytokine Receptors", Science 261:1739-1744.
Yan et al., 1993 "A Novel Receptor Tyrosine Phosphatase-.alpha. That is Highly Expressed in the Nervous System", J Biol Chem 268:24880-24886.
Goldstein, 1992 "Protein-Tyrosine Phosphatases and the Regulation of Insulin Action", J Cell Biochem 48:33-42.
Hegde et al., 1992, "SCH 45752--An Inhibitor of Calmodulin-Sensitive Cyclic Nucleotide Phosphodiesterase Activity", J Antibiotics 48:207-213.
Pot and Dixon, 1992, "A Thousand and Two Protein Tyrosine Phosphatases", Biochem Biophys Acta 1136:35-43.
Spivak et al., 1992, "Protein Kinases and Phosphatases Are Involved in Erythropoletin-mediated Signal Transduction", Exp Hermatol 20:500-504.
Saito and Streuli, 1991, "Molecular Characterization of Protein Tyrosine Phosphatases", Cell Growth Differ 2:59-65.
Fischer et al., 1991, "Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes", Science 352:401-406.
Shen et al., 1991, "A Protein-Tyrosine Phosphatase With Sequence Similarity to the SH2 Domain of the Protein-Tyrosine Kinases", Nature 352:736-739.
Kaplan et al., 1990, "Cloning of Three Human Tyrosine Phosphatases Reveals a Multigene Family of Receptor-linked Protein-Tyrosine-Phosphatases Expressed in Brain", Proc Natl Acad Sci 87:7000-7004.
Lund et al., 1990, "Prevention of Insulin-Dependent Diabetes Mellitus in Non-Obese Diabetic Mice by Transgenes Encoding Modified I-A .beta.-Chain or Normal I-E .alpha.-Chain", Nature 345:727-729.
Cool et al., 1989, "cDNA Isolated From a Human T-Cell Library Encodes a Member of the Protein-Tyrosine-Phosphatase Family", Proc Natl Acad Sci 86:5257-5261.
Solomon et al., 1989, "Studies of Insulin Resistance in the Streptozocin Diabetic and BB Rat: Activation of Low Km cAMP Phosphodiesterace by Insulin", Am J Med Sci 297:372-376.
Charbonneau et al., 1989, "Human Placenta Protein-Tyrosine-Phosphatase Amino Acid Sequence and Relationship to a Family of Receptor-like Proteins", Proc. Natl Acad Sci 86:5252-5256.
Charbonneau et al., 1988, "The Leukocyte Antigen (CD45) A Positive Receptor-linked Protein Tyrosine Phosphatase", Proc. Nat Acad Sci 85:7182-7186.
Suganuma et al., 1988, "Okadaic Acid: An Additional Non-Phorbol-12-Teterdecanoate-13-acetate-type Tumor Promoter", Proc Natl Acad Sci 85:1768-1771.
Slamon et al., 1987, "Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2 ineu Oncogene", Science 235:177-182.
Dubyak and Kleinzeller, 1980, "The Insulin-mimetic Effects of Vanadate in Isolated Rat Adipocytes", J Biol Chem 255:5306-5312
Shechter and Karlish, 1980, "Insulin-like Stimulation of Glucose Oxidation in Rat Adipocytes by Vanadyl (IV) Ions", Nature 284:556-558.
McMahon Gerald
Tang Peng C.
Cross Laura R.
Richter Johann
Sugen Inc.
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