Methods of inhibiting or inducing bone formation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S002600, C514S008100, C424S085100

Reexamination Certificate

active

07041645

ABSTRACT:
The present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of recombinant bone morphogenic proteins (rBMPs) and its use in therapy, especially in the treatment of orthopaedic and dental patients. Specifically, the present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of at least two rBMPs or their monomers or mutants in a suitable carrier system.

REFERENCES:
patent: 4563489 (1986-01-01), Urist
patent: 5399677 (1995-03-01), Wolfman et al.
patent: 5631142 (1997-05-01), Wang et al.
patent: 5854207 (1998-12-01), Lee et al.
patent: 6180606 (2001-01-01), Chen et al.
patent: 6245889 (2001-06-01), Wang et al.
patent: 103278 (1999-05-01), None
patent: WO 92/09697 (1992-06-01), None
patent: WO 93/09229 (1993-05-01), None
patent: WO 00/56879 (2000-09-01), None
patent: WO 00/64460 (2000-11-01), None
Wells, 1990, Biochemistry 29:8509-8517.
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, Merz et al., eds., Birkhauser, Boston, pp. 492-495.
Vukicevic et al., 1996, PNAS USA 93:9021-9026.
Massague, 1987, Cell 49:437-438.
Pilbeam et al., 1993, Bone 14:717-720.
Isobe et al., “Bone morphogenetic protein encapsulated with a biodegradable and biocompatible polymer,”J. Biomed. Mat. Res., 32:433-438 (1996).
Weber et al., “Disulfide Bridge Conformers of Mature BMP Are Inhibitors for Hetertopic Ossification,”Biochem. and Biophys. Res. Comm., 286:554-558 (2001).
Wozney and Rosen, “Bone Morphogenetic Protein and Bone Morphogenetic Protein Gene Family in Bone Formation and Repair,”Clin. Ortho. and Rel. Res., 346:26-37 (1998).
DiCesare et al., “Effects of indomethacin on demineralized bone-induced heterotopic ossification in the rat,”J. Orthop. Res., 9:855-861 (1991).
Muthukumaran and Reddi, “Dose-dependence of the threshold for optimal bone induction by collagenous bone matrix and osteogenin-enriched fraction,”Collagen Rel. Res., 8:433-441 (1988).
O'Connor, “Animal models of heterotopic ossification,”Clin. Orthop.346:71-80 (1998).
Wozney “Bone Morphogenetic Proteins,”Progress in Growth Factor Research, 1:267-280 (1989).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of inhibiting or inducing bone formation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of inhibiting or inducing bone formation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of inhibiting or inducing bone formation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3652438

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.