Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
1999-12-13
2010-12-28
Parkin, Jeffrey S. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C424S148100, C424S160100
Reexamination Certificate
active
07858298
ABSTRACT:
This invention provides methods for inhibiting fusion of HIV-1 to CD4+cells which comprise contacting CD4+cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4+cells is inhibited. This invention also provides methods for inhibiting HIV-1 infection of CD4+cells which comprise contacting CD4+cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4+cells is inhibited, thereby inhibiting the HIV-1 infection. This invention provides non-chemokine agents capable of binding to the chemokine receptor and inhibiting fusion of HIV-1 to CD4+cells. This invention also provides pharmaceutical compositions comprising an amount of the non-chemokine agent capable of binding to the chemokine receptor and inhibiting fusion of HIV-1 to CD4+cells effective to prevent fusion of HIV-1 to CD4+cells and a pharmaceutically acceptable carrier.
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Allaway Graham P.
Litwin Virginia M.
Maddon Paul J.
Olson William C.
Cooper & Dunham LLP
Parkin Jeffrey S.
Progenics Pharmaceuticals Inc.
White John P.
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