Methods of inhibiting B lymphocytes using antibodies to...

Details Methods of inhibiting B lymphocytes using antibodies to... Methods of inhibiting B lymphocytes using antibodies to...

2000-06-08

2011-12-06

Bunner, Bridget E (Department: 1647)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S133100, C424S139100, C424S141100, C424S158100, C424S178100, C530S387100, C530S387300, C530S388100, C530S389100, C530S387900, C530S399000

Reexamination Certificate

active

08071092

ABSTRACT:
The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

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