Methods of inhibiting angiogenesis and tumor growth, and treatin

Details Methods of inhibiting angiogenesis and tumor growth, and treatin Methods of inhibiting angiogenesis and tumor growth, and treatin

1994-01-04

1997-07-08

Burn, Brian M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

514177, 514178, 514179, 514180, 514181, 514912, 514913, A61K 3156

Patent

active

056461364

ABSTRACT:
Methods for treating angiogenesis, tumors, and ocular hypertension with steroids are disclosed herein. The steroids have angiostatic activity with reduced glucocorticoid activity.

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Folkman et al., Angiogenesis and Inflammation; Basic Principles and Clnical Correlates, Second Edition, pp. 821-839 (1992).
Teicher et al., Antiangiogenic Agents Potentiate Cytotoxic Cancer Therapies Against Primary and Metastatic Disease; Cancer Research 52, pp. 6702-6704 (1992).
International Search Report, PCT/US95/00165, May 3, 1995.

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