Methods of inducing T cell unresponsiveness to donor tissue or o

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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4241301, 4241331, 4241341, 4241411, 4241431, 4241541, 4241731, 514 2, 514 8, 514885, 5303871, 5303873, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875, 530350, A61K39/395;35/26

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059025859

ABSTRACT:
Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, sklin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.

REFERENCES:
patent: 5474771 (1995-12-01), Lederman
patent: 5683693 (1997-11-01), Noelle et al.
Markees et al., Transplant Proc. 28:814-815 (1996).
Gerritse et al., PNAS 93:2499-2504 (1996).
Tisch et al., PNAS 91:437-438 (1994).
Sharkey et al., Cancer Res. (Suppl) 55:59355 (1995).
Larsen et al., Transplantation 61:4-9 (1996).
Rossini et al., Cell Transplantation 5:49-52 (1996).
Bhatia et al., 9th Intl. Congress of Immunology, San Francisco, CA, USA, p. 311, (1995).
Pulito et al., J. Immunol., 150:2840-2850 (1996), p. 2840 only.
Durie, F., et al., "Allogeneic Tolerance Induced by Treatment with an Antibody to the Ligand for CD40,", FASEB Journal, Abstracts Part 1, Ab. No. 2763, vol. 8, No. 4, p. a477. (1994).
Monaco, Immunomethods 2:159-170 (1993).
Wee et al. Transplantation 58:261-264 (1994).
Paul et al. Fundamental Immunology Raven Press P. 242 Only (1993).
Marshall et al. J. Clin. Immunology 3(3) :165-173 (1993).
Clark and Ledbetter, (1994) "How B and T Cells . . . other", Nature, 367:425-428.
Aruffo, et al., (1993) "The CD40 ligand . . . Hyper-IgM Syndrome", Cell, 72:291-300.
Korthauer, et al. (1993) "Deffective expression . . . hyper-IgM" Nature 361:539-541.
DiSanto, et al., (1993) "CD40 ligand mutations . . . hyper-IgM" Science 259:541-543.
Allen, et al., (1993) "CD40 ligand. . . Syndrome". Science 259:990-993.
Ranheim, et al. (1993) "Activated T cells . . . signal" J. Exp. Med. 177:925-935.
Foy, et al. (1993) "In Vivo . . . gp39" J. Exp. Med. 178:1567-1575.
Lin, et al. (1993) "Long-Term Acceptance . . . Transfusion" J. Exp. Med. 178:1801-1806.
Harris (1993) "Therapeutic antibodies . . . age" TIBTECH 11:42-44.
Noelle et al. (1992) "A 39-kDa protein . . . B cells" Proc. Natl. Acad. Sci. USA 89:6550-6554.
Noelle et al. (1992) "CD40 and . . . activation" Immun. Today 13:431-433.
Hollenbaugh et al. (1992) "The human T cell . . . activity" EMBO Journal 11:4313-4321.
Armitage et al. (1992) "Molecular . . . CD40" Nature 357:80-82.
Lane et al. (1992) Activated human . . . lymphocytes Eur. J. Immuno. 22:2573-2578.
Lederman et al. (1992) "Identification of a . . . (Help)" J. Exp. Med. 175:1091-1101.
Spriggs et al. (1992) "Recombinant Human . . . E secretion" J. Exp. Med. 176:1543-1550.
Lederman et al. (1992) "Molecular interactions . . . follicles" J. Immuno. 149(12):3817-3826.
Fanslow et al. (1992) "Soluble forms of CD40 . . . B cells" J. Immuno. 149:655-660.
Eynon and Parker, (1992) "Small B Cells . . . Antigen" J. Exp. Med. 175:131-138.
Linsley et al. (1992) "Immunosuppression in Vivo . . . Molecule" Science 257:792-795.
Lenschow et al. (1992) "Long-term Survival . . . CTLA4Ig" Science 257:789-790.
Turka et al. (1992) "T-cell . . . in vivo" Proc. Natl. Acad. Sci. USA 89:11102-11105.
Waldmann (1992) "Immune Receptors . . . Rejection" Annu. Rev. Immuno. 10:675-704.
Noelle and Snow (1992) "T helper Cells" Curr. Op. Immuno. 4:333-337.
Yellin et al. (1991) "A huan CD4-T cell . . . function" J. Immuno. 147:3389-3395.
Waldmann et al. (1991) "Monoclonal . . . therapy" Science 52:1657-1662.
Bartlett et al. (1990) "Cognate interactions . . . B Cells" J. Immuno. 145(12):3956-3962.
Hodgkin et al. (1990) "Separation of . . . lymphokines" J. Immuno. 145(7):2025-2034.
Aruffo et al. (1990) "CD44 is the . . . Hyaluronate" Cell 61:1303-1313.
Stamenkovic et al. (1989) "A B-lymphocyte . . . carcinomas" The EMBO J. 8(5):1403-1410.
Paulie et al. (1989) "The human B . . . transduction" J. Immuno. 142:590-595.
Sharabi et al. (1989) "Mixed chimerism and . . . regimen" J. Exp. Med. 169:493-502.
Dillman (1989) "Monoclonal . . . Cancer" Annals Inter. Med. 111(7):592-603.
Waldmann (1989) "Manipulation . . . Antibodies" Annu. Rev. Immuno. 7:407-444.
Cobboid et al. (1986) "Monoclonal . . . tolerance" Nature 323:164-166.

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