Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1994-04-25
1999-02-09
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241331, 4241341, 4241431, 4241441, 4241731, 514 2, 514 8, 514 12, A61K 39395, A61K 3702, A61K 3704
Patent
active
058690492
ABSTRACT:
Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor on the surface of the T cell which inhibits interaction of the ligand on the antigen presenting cell with the receptor on the T cell. In a preferred embodiment, the cell which presents antigen to the T cell is a B cell and the receptor on the surface of the T cell which mediates contact-dependent helper effector function is gp39. Preferably, the antagonist is an anti-gp39 antibody or a soluble gp39 ligand (e.g., soluble CD40). The methods of the invention can be used to induce T cell tolerance to a soluble antigen or to an allogeneic cell. The methods of the invention can also be used to induce tolerance in cases of bone marrow transplantation and other organ transplants and to inhibit graft-versus-host disease.
REFERENCES:
patent: 5474771 (1995-12-01), Lederman
Castle, B.E. et al. (1993) "Regulation of Expression of the Ligand for CD40 on T Helper Lymphocytes" J. Immunol. 151(4): 1777-1788.
Marshall, L.S. et al. (1993) "The Molecular Basis for T Cell Help in Humoral Immunity: CD 40 and its Ligand, gp39" J. Clin. Immunol. 13(3): 165-174.
Clark and Ledbetter, (1994) "How B and T cells talk to each other", Nature, vol. 367, pp. 425-428.
Aruffo, et al., (1993) "The CD40 ligand, gp39, is defective in activated T cells from patients with X-Linked Hyper-IgM Syndrome", Cell, vol. 72, pp. 291-300.
Korhthauer, et al., (1993) "Defective expression of T cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM", Nature, vol. 361, pp. 539-541.
DiSanto, et al., (1993) "CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM", Nature, vol. 361, pp. 541-543.
Allen, et al., (1993) "CD40 ligand gene defects responsible for X-Linked Hyper-IgM Syndrome", Science, vol. 259, pp. 990-993.
Ranheim, et al., (1993) "Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal", Journal of Experimental Medicine, vol. 177, pp. 925-935.
Foy, et al., (1993) "In Vivo CD40-gp39 Interactions are essential for Thymus-dependent Hummoral Immunity. II. Prolonged suppression of the Humoral Immune Response by an antibody to the ligand for CD40, gp39", Journal of Experimental Medicine, vol. 178, pp. 1567-1575.
Lin, et al., (1993) "Long-Term Acceptance of Major Histocompatability Complex Mismatched Cardiac Allografts Induced by CTLA41g Plus Donor-specific Transfusion", Journal of Experimental Medicine, vol. 178, pp. 1801-1806.
Harris (1993) "Therapeutic antibodies--the coming of age", TIBTECH, vol. 11, pp. 42-44.
Noelle et al., (1992) "CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation", Immunology Today, vol. 13, pp. 431-433.
Noelle et al., (1992) "A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells", Proceedings of the National Academy of Sciences, vol. 89, pp. 6550-6554.
Hollenbaugh, et al., (1992) "The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity", The EMBO Journal, vol. 11, No. 12, pp. 4313-4321.
Armitage, et al., (1992) "Molecular and biological characterization of a murine ligand for CD40", Nature, vol. 357, pp. 80-82.
Lane, et al., (1992) "Activated human T cells express a ligand for the human B cell-associated CD40 which participates in T-cell-dependent activation of B lymphocytes", European Journal of Immunology, vol. 22, pp. 2573-2578.
Lederman, et al., (1992) "Identification of a novel surface protein on activated CD4.sup.+ T cells that induces contact-dependent B cell differentiation (Help)", Journal of Experimental Medicine, vol. 175, pp. 1091-1101.
Spriggs, et al., (1992) "Recombinant Human CD40 ligand stimulates B cell proliferation and Immunoglobulin E secretion", Journal of Experimental Medicine, vol. 176, pp. 1543-1550.
Lederman, et al., (1992) "Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles", Journal of Immunology, vol. 149, No. 12, pp. 3817-3826.
Fanslow, et al., (1992) "Soluble forms of CD40 inhibit biologic responses of human B cells", Journal of Immunology, vol. 149, No. 2, pp. 655-660.
Eynon and Parker, (1992) "Small B Cells as Antigen-presenting Cells in the Induction of Tolerance to Soluble Protein Antigen", Journal Experimental Medicine, vol. 175, pp. 131-138.
Linsley, et al., (1992) "Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule", Science, vol. 257, pp. 792-795.
Lenschow, et al., (1992) "Long-term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA41g", Science, vol. 257, pp. 789-790.
Turka, et al., (1992) "T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo" Proceedings of the National Academy of Sciences, vol. 89, pp. 11102-11105.
Waldmann (1992) "Immune Receptors: Targets for Therapy of Leukemia/Lymphoma, Autoimmune Diseases and for the Prevention of Allograft Rejection", Annu. Rev. Immunol., vol. 10, pp. 675-704.
Noelle and Snow, (1992) "T helper cells", Current Opinion in Immunology, vol. 4, pp. 333-337.
Yellin, et al., (1991) "A human CD4-T cell Leukemia subclone with contact-dependent helper function", Journal of Immunology, vol. 147, pp. 3389-3395.
Waldmann et al., (1991) "Monoclonal antibodies in diagnosis and therapy", Science, vol. 52, pp. 1657-1662.
Bartlett, et al., (1990) "Cognate interactions between helper T cells and B cells", Journal of Immunology, vol. 145, No. 12, pp. 3956-3962.
Hodgkin, et al., (1990) "Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines", Journal of Immunology, vol. 145, No. 7, pp. 2025-2034.
Aruffo, et al., (1990) "CD44 Is the Principal Cell Surface Receptor for Hyaluronate", Cell, vol. 61, pp. 1303-1313.
Stamenkovic, et al., (1989) "AB-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas", The EMBO Journal, vol. 8, No. 5, pp. 1403-1410.
Paulie, et al., (1989) "The human B Lymphocyte and Carcinoma Antigen, CDw40, is a Phosphoprotein involved in growth signal transduction", Journal of Immunology, vol. 142, pp. 590-595.
Sharabi, et al., (1989) "Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen", Journal of Experimental Medicine, vol. 169, pp. 493-502.
Dillman, (1989) "Monoclonal antibodies for treating Cancer", Annals of Internal Medicine, vol. 111, No. 7, pp. 592-603.
Waldmann (1989) "Manipulation of T cell responses with monoclonal antibodies", Annu. Rev. Immunol., vol. 7, pp. 407-444.
Cobbold, et al., (1986) "Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance", Nature, vol. 323, pp. 164-166.
Larsen et al. Transplantation 61: 4-9 (1996).
Stuber et al. J Exp Med. 183:693-698 (1995).
Gray et al., J Exp. Med. 180:141-155 (1994).
Monaco Immunomethods 2:159-170 (1993).
Wee et al. Transplantation 58:261-264 (1994).
Paul (Ed) Fundamental Immunology Raven Press 1993 p. 242 only.
Buhlmann et al. Immunity 2:645-653 (1995).
Durie Fiona H.
Foy Teresa M.
Greiner Dale L.
Mordes John P.
Noelle Randolph J.
Feisee Lila
Gambel Phillip
Trustees of Dartmouth College
University of Massachusetts Medical Center
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