Methods of inducing ovulation

Details Methods of inducing ovulation Methods of inducing ovulation

2006-07-18

2006-07-18

Weber, Jon (Department: 1653)

Chemistry: analytical and immunological testing

Pregnancy or ovulation

C435S069200, C530S313000, C530S388240, C514S002600

Reexamination Certificate

active

07078236

ABSTRACT:
The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.

REFERENCES:
patent: 6423710 (2002-07-01), Martins et al.
Tsafriri et al. (1996) Oocyte maturation involves compartmentalization and opposing changes of cAMP levels in follicular somatic and germ cells: studies using selective phosphodiesterase inhibitors. Dev. Biol. vol. 178, pp. 393-402.
Taylor et al. (1997) Src tyrosine kinase activity in rat thecal-interstitial cells and mouse TM3 Leydig cells is positively associated with cAMP-specific phosphodiesterase activity. Mol. Cell. Endocrinol. vol. 126, pp. 91-100.
Ovulation Calendar (2005) “luteal phase” //www.oulation-calendar.com/hlp-d04-luteal-phase.html, p. 1.

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