Methods of increasing sphincter competence

Details Methods of increasing sphincter competence Methods of increasing sphincter competence

1997-01-07

2000-09-05

Park, Hankyel T.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an inorganic compound

549 49, 546202, 508301, A61K 5100, C07D33352, C07D40900

Patent

active

061138762

ABSTRACT:
A method of increasing sphincter competence comprising administering to a human in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidino, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.
Also encompassed by the invention is a method of inhibiting urinary or fecal incontinence, or gastroesophageal disease or its symptoms, which includes administering to a human in need thereof an effective amount of a compound of formula 1.

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Isselbacher, et al., "Diseases of the Esophagus", Harrison's Principles of Internal Medicine, (9), 239, (1365-1367).
Harvey, "Gastric Antacids and Digestants" Goodman and Gilman's ,The Pharmacologic Basis of Therapeutics, (6), 42, (988-995).
Timiras et al., "The Urinary System", Hormones and Aging, 8, (141-142).
Isselbacher, et al., "Dysuria, Incintinence, and Enuresis", Harrison's Principles of Internal Medicine, (9), 44, (222-223).
U.S. application No. 09/063152, Cullinan, filed Apr. 20, 1998.

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