Methods of increasing platelet and hematopoietic stem cell...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S085100, C424S198100, C424S093100, C424S093700, C435S325000, C514S007900, C530S300000

Reexamination Certificate

active

08067367

ABSTRACT:
A method of increasing hematopoietic stem cell production is disclosed. The method includes administering a TPO mimetic compound to a subject. Pharmaceutical compositions including a TPO mimetic compound and a pharmaceutically acceptable carrier are also disclosed.

REFERENCES:
patent: 3654090 (1972-04-01), Wilhelmus et al.
patent: 3940475 (1976-02-01), Gross
patent: 4179337 (1979-12-01), Davis et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4496689 (1985-01-01), Mitra
patent: 4612132 (1986-09-01), Wollenberg et al.
patent: 4640835 (1987-02-01), Shimizu et al.
patent: 4668619 (1987-05-01), Greenquist et al.
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 4791192 (1988-12-01), Nakagawa et al.
patent: 5141851 (1992-08-01), Brown et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5198424 (1993-03-01), McEver
patent: 5270170 (1993-12-01), Schatz et al.
patent: 5326558 (1994-07-01), Turner et al.
patent: 5338665 (1994-08-01), Schatz et al.
patent: 5358934 (1994-10-01), Borovsky et al.
patent: 5359115 (1994-10-01), Campbell et al.
patent: 5384331 (1995-01-01), Kogan et al.
patent: 5411942 (1995-05-01), Widmer et al.
patent: 5420328 (1995-05-01), Campbell
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5432018 (1995-07-01), Dower et al.
patent: 5639603 (1997-06-01), Dower et al.
patent: 5723286 (1998-03-01), Dower et al.
patent: 5770358 (1998-06-01), Dower et al.
patent: 5869451 (1999-02-01), Dower et al.
patent: 5932546 (1999-08-01), Barrett et al.
patent: 5989833 (1999-11-01), Charon et al.
patent: 6060052 (2000-05-01), Murray et al.
patent: 6083913 (2000-07-01), Dower et al.
patent: 6121238 (2000-09-01), Dower et al.
patent: 6251864 (2001-06-01), Dower et al.
patent: 6465430 (2002-10-01), Dower et al.
patent: 6506362 (2003-01-01), Dower et al.
patent: 6835809 (2004-12-01), Liu et al.
patent: 7091311 (2006-08-01), Dower et al.
patent: 7189827 (2007-03-01), Feige
patent: 7576056 (2009-08-01), MacDonald et al.
patent: 7615533 (2009-11-01), Yurkow et al.
patent: 7723295 (2010-05-01), MacDonald et al.
patent: 2002/0187124 (2002-12-01), Takahashi
patent: 2003/0158116 (2003-08-01), Dower et al.
patent: 2004/0028649 (2004-02-01), Gianni
patent: 2005/0137133 (2005-06-01), MacDonald et al.
patent: 2006/0040866 (2006-02-01), MacDonald et al.
patent: 2006/0058240 (2006-03-01), Dower et al.
patent: 2006/0210542 (2006-09-01), Yurkow et al.
patent: 2007/0148091 (2007-06-01), Dower et al.
patent: 2008/0119384 (2008-05-01), Yurkow et al.
patent: 2009/0214489 (2009-08-01), Dower et al.
patent: 0 450 715 (1991-10-01), None
patent: 0 613 683 (1994-09-01), None
patent: 0 690 127 (1995-01-01), None
patent: 0 668 352 (1995-02-01), None
patent: 0 675 201 (1995-03-01), None
patent: 0 690 127 (1996-01-01), None
patent: 0 783 003 (1997-07-01), None
patent: 2 186 579 (1987-08-01), None
patent: 2 285 446 (1995-07-01), None
patent: WO 90/15070 (1990-12-01), None
patent: WO 90/15070 (1990-12-01), None
patent: WO 91/07988 (1991-06-01), None
patent: WO 91/07988 (1991-06-01), None
patent: WO 91/08752 (1991-06-01), None
patent: WO 91/08752 (1991-06-01), None
patent: WO 93/25221 (1993-12-01), None
patent: WO 93/25221 (1993-12-01), None
patent: WO 94/17784 (1994-08-01), None
patent: WO-95/05843 (1995-03-01), None
patent: WO 95/11922 (1995-05-01), None
patent: WO 95/11922 (1995-05-01), None
patent: WO 95/18858 (1995-07-01), None
patent: WO 95/18858 (1995-07-01), None
patent: WO 95/21626 (1995-08-01), None
patent: WO 95/21626 (1995-08-01), None
patent: WO 95/21919 (1995-08-01), None
patent: WO 95/21919 (1995-08-01), None
patent: WO 95/21920 (1995-08-01), None
patent: WO 95/21920 (1995-08-01), None
patent: WO 95/28907 (1995-11-01), None
patent: WO 95/28907 (1995-11-01), None
patent: WO-95/34326 (1995-12-01), None
patent: WO-96/14293 (1996-05-01), None
patent: WO 96/17062 (1996-06-01), None
patent: WO 96/17062 (1996-06-01), None
patent: WO 96/ 17062 (1996-06-01), None
patent: WO 96/17067 (1996-06-01), None
patent: WO 96/17067 (1996-06-01), None
patent: WO-96/34016 (1996-10-01), None
patent: WO 96/40189 (1996-12-01), None
patent: WO 96/40750 (1996-12-01), None
patent: WO 98/25965 (1998-06-01), None
patent: WO-9825965 (1998-06-01), None
patent: WO 01/21180 (2001-03-01), None
patent: WO-02/051861 (2002-07-01), None
patent: WO 02/076612 (2002-10-01), None
patent: WO-2004/026332 (2004-04-01), None
patent: WO-2005/023834 (2005-03-01), None
Fibbe et al. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 86(9): 3308-3313, 1995.
Cwirla et al. Peptide agonist of the thrombopoietic receptor as potent as the natural cytokine. Science 276: 1696-1699, 1997.
Dower et al. Peptide agonists of the thrombopoietin receptor. Stem Cells 16(Suppl 2): 21-29, 1998.
Kuter et al. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 100(10): 3457-3469, 2002.
Kaushansky et al., “Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoletin”, Nature, vol. 369, pp. 568-571 (1994).
Solar et al., “Role of c-mpl in Early Hematopoiesis”, Blood, vol. 92, pp. 4-10 (1998).
Ku et al., “Thrombopoietin, the Ligand for the Mpl Receptor, Synergizes With Steel Factor and Other Early Acting Cytokines in Supporting Proliferation of Primitive Hematopoletic Progenitors of Mice”, Blood, vol. 87, pp. 4544-4551 (1996).
Sitnicka et al., “The Effect of Thrombopoletin on the Proliferation and Differentiation of Murine Hematopoletic Stem Cells”, Blood, vol. 87, pp. 4998-5005 (1996).
Kimura et al., “Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin”, Proc. Natl. Acad. Sci. U.S.A., vol. 95, pp. 1195-1200 (1998).
Ballmaier et al., “c-mpl mutations are the cause of congenital emegakaryocytic thrombocytopenia”, Blood, vol. 97, pp. 139-146 (2001).
Fox et al., “Thrombopoietin expands hematopoletic stem cells after transplantation”, J. Clin. Invest., vol. 110, pp. 389-394 (2002).
International Search Report dated Mar. 3, 2004 for corresponding Appln. No. PCT/US03/29701.
International Preliminary Examination Report dated Apr. 3, 2006 for corresponding Appln. No. PCT/US03/29701.
Barker et al. “Cyclic RGD Peptide Analogues as Antiplatelet Antithrombotics”, J. Med. Chem. vol. 35, pp. 2040-2048 (1992).
Bartley et al. “Identification and Cloning of a Megakaryocyte Growth and Development Factor That Is a Ligand for the Cytokine Receptor Mpl”, Cell, vol. 77, pp. 1117-1124 (1994).
Basser et al., “Randomized, Blinded, Placebo-Controlled Phase I Trail of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor With Filgrastim After Dose-Intensive Chemotherapy in Patients With Advanced Canter”, Blood, vol. 89, No. 9, pp. 3118-3128 (1997).
Bazan, “Structural design and molecular evolution of a cytokine receptor superfamily”, Proc. Natl. Acad. Sci. USA, vol. 87, pp. 6934-6938 (1990).
Berger et al. “A New Method for the Synthesis of Optically Active α-Amino Acids and Their NαDerivativesviaAcylamino Malonates”, J. Org. Chem., vol. 38, No. 3, pp. 457-460 (1973).
Caras et al. “Signal Peptide for Protein Secretion Directing Glycophospholipid Membrane Anchor Attachment”, Science, vol. 243, pp. 1196-1198 (1989).
Cwirla et al. “Peptides on Phage: A Vast Library of Peptides for Identifying Ligands”, Proc. Natl. Acad. Sci. USA, vol. 87, pp. 6378-6382 (1990).
Daumas et al. “Gramicidin A analogs: influence of the substitution of the tryptophans by naphthylalanines”, Biochimie, vol. 71, pp. 77-81 (1989).
de Sauvage et al. “Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand”, Nature, vol. 369, pp. 533-538 (1994).
Dexter et al. “Growth of Factor-Dependent Hemopoietic Precursor Cell Lines”, J. Exp. Med., vol. 152, pp. 1036-1047 (1980).
Dower et al. “The Search

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