Methods of increasing distribution of nucleic acids

Details Methods of increasing distribution of nucleic acids Methods of increasing distribution of nucleic acids

2007-02-27

2007-02-27

Whiteman, Brian (Department: 1635)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

Reexamination Certificate

active

10132681

ABSTRACT:
This invention provides a method of increasing the volume of distribution of a nucleic acid encoding a therapeutic agent in a tissue in a subject during localized delivery, comprising administering to the tissue in the subject a nucleic acid encoding a therapeutic agent and a facilitating agent, whereby the inclusion of the facilitating agent increases the volume of distribution of the nucleic acid encoding a therapeutic agent in the tissue.

REFERENCES:
patent: 5922356 (1999-07-01), Koseki et al.
patent: 6121246 (2000-09-01), Isner
patent: 6309634 (2001-10-01), Bankiewicz et al.
patent: 6410300 (2002-06-01), Samulski et al.
patent: 2002/0068717 (2002-06-01), Borrelli
patent: 2002/0141980 (2002-10-01), Bankiewicz et al.
Orkin et al., Dec. 7, 1995, “Report and Recommendation of the Panel to Assess the NIH investment in Research and Gene Therapy”, issued by the National Institute of Health.
Handa et al., J Gen Virol. Aug. 2000;81(Pt 8):2077-84.
Chung et al., Journal of Virology 72:1577-1585, 1998.
Verma, Nature, vol. 389, pp. 239-242, 1997.
Provisional Application 60/251,713.
Anderson et al., Nature, vol. 392, pp. 25-30, 1998.
Kibbe et al., Arch Surg, 2000:133:191-197.
Trarbach et al. Cytotherapy, 2000: 2:429-438.
Hacker et al., Gene Therapy, 2001: 8:966-868.
Gorecki, Exper Opin. Emerging Drugs, 6:187-198, 2001.
Agrawal et al., “Cell-cycle kinetics and VSV-G pseudotyped retrovirus-mediated gene transfer in blood-derived CD34+ cells.”Exp. Hematol. 24(6):738-747 (May 1996).
Bajetto et al., “Glial and Neuronal Cells Express Functional Chemokine Receptor CXCR4 and Its Natural Ligand Stromal Cell-Derived Factor 1.”J Neurochem73:2348-2357 (1999).
Bankiewicz et al., “Convection-Enhanced Delivery of AAV Vector in Parkinsonian Monkeys;In VivoDetection of Gene Expression and Restoration of Dopaminergic Function Using Pro-drug Approach.”Exp. Neurol. 164(1):2-14 (Jul 2000).
Bankiewicz et al., “Practical Aspects of the Development ofex Vivoandin VivoGene Therapy for Parkinson's Disease.”Exp. Neurol. 144:147-156 (Mar. 1997).
Bernfield et al., “Functions of Cell Surface Heparan Sulfate Proteoglycans.”Annu. Rev. Biochem. 68:729-777 (1999).
Betz et al., “Gene Transfer to Rodent Brain with Recombinant Adenoviral Vectors: Effects of Infusion Parameters, Infectious Titer, and Virus Concentration on Transduction Volume.”Exp. Neurol. 150:136-142 (Mar. 1998).
Bhat et al., “Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type 1 envelope glycoprotein gp120.”Proc. Natl. Acad. Sci. USA88:7131-7134 (Aug. 1991).
Chung et al., “A27L Protein Mediates Vaccinia Virus Interaction with Cell Surface Heparan Sulfate.”J. Virol. 72(2)1577-1585 (Feb. 1998).
Cocchi et al., “The V domain of herpes virus lg-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D.”Proc. Natl. Acad. Sci. USA95:15700-15705 (Dec. 1998).
Cunningham et al., “Distribution of AAV-TK Following Intracranial Convection-Enhanced Delivery Into Rats.”Cell Transplant. 9:585-594 (2000).
Dowd et al., “Heparan Sulfate Mediates bFGF Transport through Basement Membrane by Diffusion with Rapid Reversible Binding.”J. Biol. Chem. 274(8):5236-5244 (Feb. 19, 1999).
Feyzi et al., “Structural Requirement of Heparan Sulfate for Interaction with Herpes Simplex Virus Type 1 Virions and Isolated Glycoprotein C.”J. Biol. Chem. 272(40):24850-24857 (Oct. 3, 1997).
Goodman et al. “Recombinant Adeno-Associated Virus-Mediated Gene Transfer Into Hematopoietic Progenitor Cells.”Blood84. 84(5):1492-1500 (Sep. 1, 1994).
Hamilton et al., “Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotropic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin.” Exp. Neurol. 168(1):155-161 (Mar. 2000).
Immergluck et al. “Viral and cellular requirements for entry of herpes simplex virus type 1 into primary neuronal cells”J. Gen Virol. 79(3):549-559 (1998).
Kordower et al., “Clinicopathological Findings Following Intraventricular Glial-Derived Neurotropic Factor Treatment in a Patient with Parkinson's Disease.”Ann. Neur. 46(3):419-424 (Sep. 1999).
Leiberman et al., “Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion”J. Neurosurg. 82(6):1021-1029 (Jun. 1, 1995).
Matsushita et al., “Adeno-associated virus vectors can be efficiently produced without helper virus.”Gene Ther. 5(7):938-945 (Jul. 1, 1998).
Mitani et al., “Transduction of Human Bone Marrow by Adenoviral Vector.”Hum. Gene Ther. 5(8):941-948 (Aug. 1994).
Naidini et al., “In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral.”Science272:263-267 (Apr. 12, 1996).
Peel and Klien, “Adeno-associated virus vectors: activity and applications in the CNS.”J. Neurosci Meth. 98(2):95-104 (2000).
Qing et al., “Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.”Nat. Am. 5(1):71-77 (1999).
Qui et al., “The Interaction of Heparin Sulfate and Adeno-Associated Virus 2.”Virology269:137-147 (2000).
Schwarzenberger et al., “Target Gene Transfer to Human Hematopoietic Progenitor Cell Lines Through the c-kit Receptor.”Blood87(2):472-478 (Jan. 15, 1996).
Summerford and Samulski, “Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions.”J. Virol. 72(2):1438-1445 (Feb. 1998).
Summerford et al., “αVβ5 integrin: a co-receptor for adeno-associated virus type 2 infection”Nat. Med 5(1):78-82 (Jan. 1999).
Tenenbaum et al., “Tropism of AAV-2 vectors for neurons of the globus pallidus.”Neuroreport11(10):2277-2283 (Jul. 14, 2000).
Trybala et al., “Interaction between Pseudorabies Virus and Heparin/Heparan Sulfate.”J. Biol. Chem. 273(9):5047-5052 (Feb. 27, 1998).
Xiao et al., “Gene Transfer by Adeno-Associated Virus Vectors into the Central Nervous System.”Exp Neurology144(1): 113-124 (Mar. 1997).

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