Methods of in vitro analysis using time-domain NMR spectroscopy

Details Methods of in vitro analysis using time-domain NMR spectroscopy Methods of in vitro analysis using time-domain NMR spectroscopy

2006-01-13

2009-06-23

Arana, Louis M (Department: 2831)

Electricity: measuring and testing

Particle precession resonance

Using a nuclear resonance spectrometer system

C324S300000

Reexamination Certificate

active

07550971

ABSTRACT:
An in vitro method of determining an analyte concentration of a sample includes placing the sample into a low-field, bench-top time-domain nuclear magnetic resonance (TD-NMR) spectrometer. The NMR spectrometer is tuned to measure a selected type of atom. A magnetic field is applied to the sample using a fixed, permanent magnet. At least one 90 degree radio-frequency pulse is applied to the sample. The radio-frequency pulse is generally perpendicular to the magnetic field. The 90 degree radio-frequency pulse is removed from the sample so as to produce a decaying NMR signal. The decaying NMR signal is measured at a plurality of times while applying a plurality of 180 degree refocusing radio-frequency pulses to the sample. The analyte concentration is calculated from the plurality of measurements associated with the decaying NMR signal and a selected model.

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International Search Report corresponding to co-pending International Patent Application No. PCT/US2006/001327, European Patent Office, dated Jun. 7, 2006, 4 pages.

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