Methods of improved skin care and the treatment of dermatologica

Details Methods of improved skin care and the treatment of dermatologica Methods of improved skin care and the treatment of dermatologica

1989-06-02

1992-06-23

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, A01N 3718, A61K 3700

Patent

active

051243130

ABSTRACT:
The present invention provides methods for treating or preventing various dermatological conditions in humans, such as dry, cracked or damaged skin resulting from exposure to sunlight (ultraviolet radiation) and wind, aging effects, general skin dryness, e.g., deficient moisture content, and mild acne. These methods comprise applying an effective amount of a composition to the affected target area, the composition comprising a retinyl palmitate-polypeptide complex of apparent molecular weight of from about 5,000 to about 7,000 daltons, and an isoprenoid compound, e.g., a carotenoid such as beta-carotene.

REFERENCES:
patent: 3729568 (1973-04-01), Kligman
patent: 3906108 (1975-09-01), Felty
patent: 4603146 (1986-07-01), Kligman
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Final Report on the Safety Assessment of Retinyl Palmitate and Retinol, Chapter 2, J. Am. Coll. Toxicol. 6(3):279-287 (1987).
Chytal et al., Vitamins and Hormones, "Cellular Vitamin A Binding Protein", Academic Press, Inc., 36:1-32 (1978).
Chytal, Hepatology, 2(2):282-287 (1982).
Chytal et al., "Cellular Retinol- and Retinoic Acid-Binding Proteins in Vitamin A Action", Fed. Proc. 38:2510-2514 (1979).
Michaelson et al., Clin, and Exp. Dermatol. 4:445-451 (1979).
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Counts, J. Soc. Cosmet. Chem. 39:235-240, Jul./Aug. (1988).

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